Comparison between two portable devices for widefield PpIX fluorescence during cervical intraepithelial neoplasia treatment

Fernanda M. Carbinatto; Natalia Mayumi Inada; Welington Lombardi; Natália Fernandez Cossetin; Cinthia Varoto; Cristina Kurachi; Vanderlei Salvador Bagnato

doi:10.1117/12.2180914

19 June 2015 Comparison between two portable devices for widefield PpIX fluorescence during cervical intraepithelial neoplasia treatment

Fernanda M. Carbinatto, Natalia Mayumi Inada, Welington Lombardi, Natália Fernandez Cossetin, Cinthia Varoto, Cristina Kurachi, Vanderlei Salvador Bagnato

Author Affiliations +

Proceedings Volume 9531, Biophotonics South America; 953140 (2015) https://doi.org/10.1117/12.2180914
Event: SPIE Biophotonics South America, 2015, Rio de Janeiro, Brazil

Abstract

The use of portable electronic devices, in particular mobile phones such as smartphones is increasing not only for all known applications, but also for diagnosis of diseases and monitoring treatments like topical Photodynamic Therapy. The aim of the study is to evaluate the production of the photosensitizer Protoporphyrin IX (PpIX) after topical application of a cream containing methyl aminolevulinate (MAL) in the cervix with diagnosis of Cervical Intraepithelial Neoplasia (CIN) through the fluorescence images captured after one and three hours and compare the images using two devices (a Sony Xperia^® mobile and an Apple Ipod^®. Was observed an increasing fluorescence intensity of the cervix three hours after cream application, in both portable electronic devices. However, because was used a specific program for the treatment of images using the Ipod^® device, these images presented better resolution than observed by the Sony cell phone without a specific program. One hour after cream application presented a more selective fluorescence than the group of three hours. In conclusion, the use of portable devices to obtain images of PpIX fluorescence shown to be an effective tool and is necessary the improvement of programs for achievement of better results.

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Fernanda M. Carbinatto, Natalia Mayumi Inada, Welington Lombardi, Natália Fernandez Cossetin, Cinthia Varoto, Cristina Kurachi, and Vanderlei Salvador Bagnato "Comparison between two portable devices for widefield PpIX fluorescence during cervical intraepithelial neoplasia treatment", Proc. SPIE 9531, Biophotonics South America, 953140 (19 June 2015); https://doi.org/10.1117/12.2180914

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