Diffuse reflectance spectroscopy of liver tissue

Nina Reistad; Jan Nilsson; Oskar Vilhelmsson Timmermand; Christian Sturesson; Stefan Andersson-Engels

doi:10.1117/12.2181008

19 June 2015 Diffuse reflectance spectroscopy of liver tissue

Nina Reistad, Jan Nilsson, Oskar Vilhelmsson Timmermand, Christian Sturesson, Stefan Andersson-Engels

Proceedings Volume 9531, Biophotonics South America; 95314E (2015) https://doi.org/10.1117/12.2181008
Event: SPIE Biophotonics South America, 2015, Rio de Janeiro, Brazil

Abstract

Diffuse reflectance spectroscopy (DRS) with a fiber-optic contact probe is a cost-effective, rapid, and non-invasive optical method used to extract diagnosis information of tissue. By combining commercially available VIS- and NIR-spectrometers with various fiber-optic contact-probes, we have access to the full wavelength range from around 400 to 1600 nm. Using this flexible and portable spectroscopy system, we have acquired ex-vivo DRS-spectra from murine, porcine, and human liver tissue. For extracting the tissue optical properties from the measured spectra, we have employed and compared predictions from two models for light propagation in tissue, diffusion theory model (DT) and Monte Carlo simulations (MC).

The focus in this work is on the capacity of this DRS-technique in discriminating metastatic tumor tissue from normal liver tissue as well as in assessing and characterizing damage to non-malignant liver tissue induced by preoperative chemotherapy for colorectal liver metastases.

Citation Download Citation

Nina Reistad, Jan Nilsson, Oskar Vilhelmsson Timmermand, Christian Sturesson, and Stefan Andersson-Engels "Diffuse reflectance spectroscopy of liver tissue", Proc. SPIE 9531, Biophotonics South America, 95314E (19 June 2015); https://doi.org/10.1117/12.2181008

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