Light excitation methods for five dimensional optoacoustic imaging

X. Luis Deán-Ben; Thomas F. Fehm; Sven Gottschalk; Erwin Bay; Daniel Razansky

doi:10.1117/12.2183985

16 July 2015 Light excitation methods for five dimensional optoacoustic imaging

X. Luis Deán-Ben, Thomas F. Fehm, Sven Gottschalk, Erwin Bay, Daniel Razansky

Proceedings Volume 9539, Opto-Acoustic Methods and Applications in Biophotonics II; 95391A (2015) https://doi.org/10.1117/12.2183985
Event: European Conferences on Biomedical Optics, 2015, Munich, Germany

Abstract

Multispectral optoacoustic tomography offers unprecedented capabilities in biological research and newly-developed systems prompt the clinical translation of this modality. By exciting tissues at multiple optical wavelengths, the distribution of spectrally-distinctive absorbers can be resolved with high resolution in deep tissues, thus enabling reading important biological parameters such as blood oxygenation or the biodistribution of photo-absorbing agents. Multispectral three-dimensional optoacoustic imaging generally comes at the expense of slow acquisition times, which limits the dynamic imaging capabilities of this modality. Recently, the feasibility of multispectral three-dimensional imaging in real time (five dimensional imaging) has been showcased. Two different illumination strategies can be used for this purpose. The first approach is based on tuning the wavelength of the laser on a per-pulse basis, which enables acquisition of large multispectral datasets on a very short time. The second approach is based on properly synchronizing the light beams from two (or more) laser sources. The performances of these two approaches are compared and discussed herein based on experiments with mice and human volunteers.

Citation Download Citation

X. Luis Deán-Ben, Thomas F. Fehm, Sven Gottschalk, Erwin Bay, and Daniel Razansky "Light excitation methods for five dimensional optoacoustic imaging", Proc. SPIE 9539, Opto-Acoustic Methods and Applications in Biophotonics II, 95391A (16 July 2015); https://doi.org/10.1117/12.2183985

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KEYWORDS

Multispectral imaging

3D image processing

Real time imaging

Tissues

3D acquisition

Tomography

Pulsed laser operation

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