An optimization-based iterative algorithm for recovering fluorophore location

Huangjian Yi; Jinye Peng; Chen Jin; Xiaowei He

doi:10.1117/12.2199032

15 October 2015 An optimization-based iterative algorithm for recovering fluorophore location

Huangjian Yi, Jinye Peng, Chen Jin, Xiaowei He

Proceedings Volume 9672, AOPC 2015: Advanced Display Technology; and Micro/Nano Optical Imaging Technologies and Applications; 96720G (2015) https://doi.org/10.1117/12.2199032
Event: Applied Optics and Photonics China (AOPC2015), 2015, Beijing, China

Abstract

Fluorescence molecular tomography (FMT) is a non-invasive technique that allows three-dimensional visualization of fluorophore in vivo in small animals. In practical applications of FMT, however, there are challenges in the image reconstruction since it is a highly ill-posed problem due to the diffusive behaviour of light transportation in tissue and the limited measurement data. In this paper, we presented an iterative algorithm based on an optimization problem for three dimensional reconstruction of fluorescent target. This method alternates weighted algebraic reconstruction technique (WART) with steepest descent method (SDM) for image reconstruction. Numerical simulations experiments and physical phantom experiment are performed to validate our method. Furthermore, compared to conjugate gradient method, the proposed method provides a better three-dimensional (3D) localization of fluorescent target.

Citation Download Citation

Huangjian Yi, Jinye Peng, Chen Jin, and Xiaowei He "An optimization-based iterative algorithm for recovering fluorophore location", Proc. SPIE 9672, AOPC 2015: Advanced Display Technology; and Micro/Nano Optical Imaging Technologies and Applications, 96720G (15 October 2015); https://doi.org/10.1117/12.2199032

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