Changes in neurocranium thickness in early childhood

Niharika Gajawelli; Sean Deoni; Jie Shi; Liang Xu; Holly Dirks; Douglas Dean; Jonathan O'Muircheartaigh; Siddhant Sawardekar; Andrea Ezis; Marvin D. Nelson; Yalin Wang; Natasha Lepore

doi:10.1117/12.2211502

22 December 2015 Changes in neurocranium thickness in early childhood

Niharika Gajawelli, Sean Deoni, Jie Shi, Liang Xu, Holly Dirks, Douglas Dean, Jonathan O'Muircheartaigh, Siddhant Sawardekar, Andrea Ezis, Marvin D. Nelson, Yalin Wang, Natasha Lepore

Author Affiliations +

Proceedings Volume 9681, 11th International Symposium on Medical Information Processing and Analysis; 96810I (2015) https://doi.org/10.1117/12.2211502
Event: 11th International Symposium on Medical Information Processing and Analysis (SIPAIM 2015), 2015, Cuenca, Ecuador

Abstract

Several developmental disorders involve shape abnormalities of the neurocranium, the most common one being craniosynostosis, that affects about 1 in 2000 infants. A key step in determining how these disorders affect neurodevelopment is to establish how the brain and neurocranium co-evolve in the normally developing child. However, due to the scarcity of normally developing infant and pediatric imaging data, there have been a lack of imaging studies pertaining to normal neurocranial development. Here, taking advantage of a large data bank of high quality brain MRI from healthy children ages 0-4 years old, and of a novel conformal geometry-based analysis pipeline, we have been determining a set of statistical atlases of the neurocranium, divided into age groups. In this first part of the study, we focus more specifically on a comparison of 1 and 2 year old infants. Characterizing neurocranium shape changes will enable us to understand how the cranial bones develop in relation to brain development. This in turn will allow a better determination of the effects of neurocranial disorders, which will help inform treatment strategies.

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Niharika Gajawelli, Sean Deoni, Jie Shi, Liang Xu, Holly Dirks, Douglas Dean, Jonathan O'Muircheartaigh, Siddhant Sawardekar, Andrea Ezis, Marvin D. Nelson, Yalin Wang, and Natasha Lepore "Changes in neurocranium thickness in early childhood", Proc. SPIE 9681, 11th International Symposium on Medical Information Processing and Analysis, 96810I (22 December 2015); https://doi.org/10.1117/12.2211502

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