CONFERENCE PROCEEDINGS
Advanced Search
Home > Proceedings > Volume 9689 > Article
Presentation
27 April 2016 1300 nm and 890 nm OCT images of oral cancer tissue engineered models and biopsy samples offer complimentary performance (Conference Presentation)
Joseph Boadi, Robert A. Byers, Jon Fernandes, Shweta Mittar, Vanessa Hearnden, Zenghai Lu, Sheila MacNeil, Martin Thornhill, Craig Murdoch, Keith D. Hunter, Alasdair McKechnie, Stephen J. Matcher
Author Affiliations +
Proceedings Volume 9689, Photonic Therapeutics and Diagnostics XII; 96891Z (2016) https://doi.org/10.1117/12.2209310
Event: SPIE BiOS, 2016, San Francisco, California, United States
Abstract
OCT has demonstrated great potential to non-invasively detect oral epithelial cancers, potentially guiding biopsy and surgical resection. On non-ophthalmic tissues the preferred illumination wavelength is 1300 nm. Previous studies on skin have shown that useful image data can also be obtained at shorter wavelengths, with systems at 1060 nm and 820 nm offering reduced depth penetration but higher contrast. Here we apply a similar comparison to tissue engineered models of oral cancer and also to human biopsy samples, generally finding a similar trend. 1300 nm multi-beam OCT (Michelson Diagnostics EX1301) visualises stromal structures and surface keratin more clearly, providing useful image contrast down to around 1 mm. This system was compared with an ultra-high resolution home-built system operating at 890 nm (2.5 micron resolution vs 7.5 micron axial resolution for the EX1301). The UHR system reveals epithelial features more clearly, especially in the DOK pre-invasive cell line model and the biopsy samples. The relative effects of center wavelength vs axial resolution in generating the differential, wavelength-dependent contrast are assessed and the OCT biopsy images are compared with contemporary histology.
Conference Presentation
© (2016) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation Download Citation
Joseph Boadi, Robert A. Byers, Jon Fernandes, Shweta Mittar, Vanessa Hearnden, Zenghai Lu, Sheila MacNeil, Martin Thornhill, Craig Murdoch, Keith D. Hunter, Alasdair McKechnie, and Stephen J. Matcher "1300 nm and 890 nm OCT images of oral cancer tissue engineered models and biopsy samples offer complimentary performance (Conference Presentation)", Proc. SPIE 9689, Photonic Therapeutics and Diagnostics XII, 96891Z (27 April 2016); https://doi.org/10.1117/12.2209310
ACCESS THE FULL ARTICLE
ORGANIZATIONAL
Sign in with credentials provided by your organization.
INSTITUTIONAL
Select your institution to access the SPIE Digital Library.
SELECT YOUR INSTITUTION
PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
PERSONAL SIGN IN
No SPIE Account? Create one
PURCHASE THIS CONTENT
SUBSCRIBE TO DIGITAL LIBRARY
50 downloads per 1-year subscription
Members: $195
Non-members: $335 ADD TO CART
25 downloads per 1 - year subscription
Members: $145
Non-members: $250 ADD TO CART
PURCHASE SINGLE ARTICLE
Includes PDF, HTML & Video, when available
Members: $17.00
Non-members: $21.00 ADD TO CART
PROCEEDINGS
 PRESENTATION
WATCH
PRESENTATION SAVE TO MY LIBRARY
GET CITATION
Advertisement
Advertisement
KEYWORDS
Biopsy
Optical coherence tomography
Cancer
Statistical modeling
Tissues
Tumor growth modeling
Performance modeling
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top