A portable cross-shape near-infrared spectroscopic detector for bone marrow lesions diagnosis

Yu Su; Ting Li

doi:10.1117/12.2210832

29 February 2016 A portable cross-shape near-infrared spectroscopic detector for bone marrow lesions diagnosis

Yu Su, Ting Li

Proceedings Volume 9689, Photonic Therapeutics and Diagnostics XII; 96894K (2016) https://doi.org/10.1117/12.2210832
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

Bone marrow lesions (BMLs) is an incidence-increasing disease which seriously hazard to human health and possibly contribute to paralysis. Delayed treatment often occurred to BMLs patients due to its characteristics such as complex and diverse clinical manifestations, non-specific, easy to misdiagnosis and etc. The conventional diagnosis methods of BMLs mainly rely on bone marrow biopsy/aspiration, which are invasive, painful, high health risk, and discontinuous which disabled monitoring and during-surgery guidance. Thus we proposed to develop a noninvasive, real-time, continuous measurement, easy-operated device aimed at detecting bone marrow diseases. This device is based on near-infrared spectroscopy and the probe is designed with a cross-shape to tightly and comfortably attach human spine. Space-resolved source-detector placement and measurement algorithm are employed. Four selected wavelength were utilized here to extract BMLs-related component contents of oxy-, deoxy-hemoglobin, fat, scattering index corresponding to fibrosis. We carried out an ink experiment and one clinical measurement to verify the feasibility of our device. The potential of NIRS in BMLs clinics is revealed.

Conference Presentation

Citation Download Citation

Yu Su and Ting Li "A portable cross-shape near-infrared spectroscopic detector for bone marrow lesions diagnosis", Proc. SPIE 9689, Photonic Therapeutics and Diagnostics XII, 96894K (29 February 2016); https://doi.org/10.1117/12.2210832

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