Synthesis and characterization of novel phthalocyanines and evaluation of photodynamic therapy properties

Aysun Korkmaz; Mehmet Kahraman; Yusuf Yilmaz

doi:10.1117/12.2214072

1 March 2016 Synthesis and characterization of novel phthalocyanines and evaluation of photodynamic therapy properties

Aysun Korkmaz, Mehmet Kahraman, Yusuf Yilmaz

Proceedings Volume 9694, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXV; 969412 (2016) https://doi.org/10.1117/12.2214072
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

In this study, phthalocyanine (Pc) compounds were synthesized and evaluated photophysical and photochemical properties for the possible application of PDT. Zinc is used as central atom for the Pc to obtain higher singlet oxygen production. The structures of the synthesized Pc are characterized by IR, UV-vis, ¹H , elemental analysis and MS. The results demonstrated that the synthesized Pc is a good candidate for the PDT applications for the cancers. The synthesized Pc will be also bound covalently to the nano surface via –SH functional group that can contribute to the production of singlet oxygen amount carrying phthalocyanines having diamagnetic metal. Thus, phthalocyanine compounds and their derivatives having high wavelength (near-IR) absorption, high triplet quantum yields, triplet state lifetime of singlet oxygen allow us to use PDT applications effectively.

Citation Download Citation

Aysun Korkmaz, Mehmet Kahraman, and Yusuf Yilmaz "Synthesis and characterization of novel phthalocyanines and evaluation of photodynamic therapy properties", Proc. SPIE 9694, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXV, 969412 (1 March 2016); https://doi.org/10.1117/12.2214072

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