The benefits of paired-agent imaging in molecular-guided surgery: an update on methods and applications
(Conference Presentation)

Kenneth M. Tichauer

doi:10.1117/12.2220408

26 April 2016 The benefits of paired-agent imaging in molecular-guided surgery: an update on methods and applications (Conference Presentation)

Kenneth M. Tichauer

Author Affiliations +

Proceedings Volume 9696, Molecular-Guided Surgery: Molecules, Devices, and Applications II; 969608 (2016) https://doi.org/10.1117/12.2220408
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

One of the major complications with conventional imaging-agent-based molecular imaging, particularly for cancer imaging, is variability in agent delivery and nonspecific retention in biological tissue. Such factors can account to “swamp” the signal arising from specifically bound imaging agent, which is presumably indicative of the concentration of targeted biomolecule. In the 1950s, Pressman et al. proposed a method of accounting for these delivery and retention effects by normalizing targeted antibody retention to the retention of a co-administered “untargeted”/control imaging agent [1]. Our group resurrected the approach within the last 5 years, finding ways to utilize this so-called “paired-agent” imaging approach to directly quantify biomolecule concentration in tissue (in vitro, ex vivo, and in vivo) [2]. These novel paired-agent imaging approaches capable of quantifying biomolecule concentration provide enormous potential for being adapted to and optimizing molecular-guided surgery, which has a principle goal of identifying distinct biological tissues (tumor, nerves, etc…) based on their distinct molecular environment. This presentation will cover the principles and nuances of paired-agent imaging, as well as the current status of the field and future applications. [1] D. Pressman, E. D. Day, and M. Blau, “The use of paired labeling in the determination of tumor-localizing antibodies,” Cancer Res, 17(9), 845-50 (1957). [2] K. M. Tichauer, Y. Wang, B. W. Pogue et al., “Quantitative in vivo cell-surface receptor imaging in oncology: kinetic modeling and paired-agent principles from nuclear medicine and optical imaging,” Phys Med Biol, 60(14), R239-69 (2015).

Conference Presentation

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Kenneth M. Tichauer "The benefits of paired-agent imaging in molecular-guided surgery: an update on methods and applications (Conference Presentation)", Proc. SPIE 9696, Molecular-Guided Surgery: Molecules, Devices, and Applications II, 969608 (26 April 2016); https://doi.org/10.1117/12.2220408

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KEYWORDS

Surgery

Tissues

Cancer

In vivo imaging

Tumors

In vitro testing

Molecular imaging

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