Visible light optical coherence tomography measure retinal oxygen metabolic response to systemic oxygenation
(Conference Presentation)

Ji Yi; Wenzhong Liu; Siyu Chen; Vadim Backman; Nader Sheibani; Christine M. Sorenson; Amani A. Fawzi M.D.; Robert A. Linsenmeier; Hao F. Zhang

doi:10.1117/12.2214803

26 April 2016 Visible light optical coherence tomography measure retinal oxygen metabolic response to systemic oxygenation (Conference Presentation)

Ji Yi, Wenzhong Liu, Siyu Chen, Vadim Backman, Nader Sheibani, Christine M. Sorenson, Amani A. Fawzi M.D., Robert A. Linsenmeier, Hao F. Zhang

Author Affiliations +

Proceedings Volume 9697, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XX; 96970I (2016) https://doi.org/10.1117/12.2214803
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

The lack of capability to quantify oxygen metabolism noninvasively impedes both fundamental investigation and clinical diagnosis of a wide spectrum of diseases including all the major blinding diseases such as age-related macular degeneration, diabetic retinopathy, and glaucoma. Using visible light optical coherence tomography (vis-OCT), we demonstrated accurate and robust measurement of retinal oxygen metabolic rate (rMRO2) noninvasively in rat eyes. The rMRO2 was calculated by concurrent measurement of blood flow and blood oxygen saturation (sO2). Blood flow was calculated by the principle of Doppler optical coherence tomography, where the phase shift between two closely spaced A-lines measures the axial velocity. The distinct optical absorption spectra of oxy- and deoxy-hemoglobin provided the contrast for sO2 measurement, combined with the spectroscopic analysis of vis-OCT signal within the blood vessels. We continuously monitored the regulatory response of oxygen consumption to a progressive hypoxic challenge. We found that both oxygen delivery, and rMRO2 increased from the highly regulated retinal circulation (RC) under hypoxia, by 0.28±0.08 μL/min (p<0.001), and 0.20±0.04 μL/min (p<0.001) per 100 mmHg systemic pO2 reduction, respectively. The increased oxygen extraction compensated for the deficient oxygen supply from the poorly regulated choroidal circulation (CC).

Conference Presentation

Citation Download Citation

Ji Yi, Wenzhong Liu, Siyu Chen, Vadim Backman, Nader Sheibani, Christine M. Sorenson, Amani A. Fawzi M.D., Robert A. Linsenmeier, and Hao F. Zhang "Visible light optical coherence tomography measure retinal oxygen metabolic response to systemic oxygenation (Conference Presentation)", Proc. SPIE 9697, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XX, 96970I (26 April 2016); https://doi.org/10.1117/12.2214803

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
PRESENTATION

WATCH
PRESENTATION SAVE TO MY LIBRARY

GET CITATION

KEYWORDS

Oxygen

Optical coherence tomography

Visible radiation

Blood circulation

Optical testing

Velocity measurements

Blood oxygen saturation

Show All Keywords

Keywords/Phrases

Search In:

Publication Years