Adaptive optics OCT using 1060nm swept source and dual deformable lenses for human retinal imaging

Yifan Jian; Sujin Lee; Michelle Cua; Dongkai Miao; Stefano Bonora; Robert J. Zawadzki; Marinko V. Sarunic

doi:10.1117/12.2213534

8 March 2016 Adaptive optics OCT using 1060nm swept source and dual deformable lenses for human retinal imaging

Yifan Jian, Sujin Lee, Michelle Cua, Dongkai Miao, Stefano Bonora, Robert J. Zawadzki, Marinko V. Sarunic

Proceedings Volume 9697, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XX; 96970W (2016) https://doi.org/10.1117/12.2213534
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

Adaptive optics concepts have been applied to the advancement of biological imaging and microscopy. In particular, AO has also been very successfully applied to cellular resolution imaging of the retina, enabling visualization of the characteristic mosaic patterns of the outer retinal layers using flood illumination fundus photography, Scanning Laser Ophthalmoscopy (SLO), and Optical Coherence Tomography (OCT). Despite the high quality of the in vivo images, there has been a limited uptake of AO imaging into the clinical environment. The high resolution afforded by AO comes at the price of limited field of view and specialized equipment. The implementation of a typical adaptive optics imaging system results in a relatively large and complex optical setup. The wavefront measurement is commonly performed using a Hartmann-Shack Wavefront Sensor (HS-WFS) placed at an image plane that is optically conjugated to the eye’s pupil. The deformable mirror is also placed at a conjugate plane, relaying the wavefront corrections to the pupil. Due to the sensitivity of the HS-WFS to back-reflections, the imaging system is commonly constructed from spherical mirrors. In this project, we present a novel adaptive optics OCT retinal imaging system with significant potential to overcome many of the barriers to integration with a clinical environment. We describe in detail the implementation of a compact lens based wavefront sensorless adaptive optics (WSAO) 1060nm swept source OCT human retinal imaging system with dual deformable lenses, and present retinal images acquired in vivo from research volunteers.

Conference Presentation

Citation Download Citation

Yifan Jian, Sujin Lee, Michelle Cua, Dongkai Miao, Stefano Bonora, Robert J. Zawadzki, and Marinko V. Sarunic "Adaptive optics OCT using 1060nm swept source and dual deformable lenses for human retinal imaging", Proc. SPIE 9697, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XX, 96970W (8 March 2016); https://doi.org/10.1117/12.2213534

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available