Measurement of cerebral blood flow rate and its relationship with brain function using optical coherence tomography

Jian Liu; Yi Wang; Yuqian Zhao; Shidan Dou; Yushu Ma; Zhenhe Ma

doi:10.1117/12.2214091

17 March 2016 Measurement of cerebral blood flow rate and its relationship with brain function using optical coherence tomography

Jian Liu, Yi Wang, Yuqian Zhao, Shidan Dou, Yushu Ma, Zhenhe Ma

Author Affiliations +

Proceedings Volume 9707, Dynamics and Fluctuations in Biomedical Photonics XIII; 97071D (2016) https://doi.org/10.1117/12.2214091
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

Activity of brain neurons will lead to changes in local blood flow rate (BFR). Thus, it is important to measure the local BFR of cerebral cortex on research of neuron activity in vivo, such as rehabilitation evaluation after stroke, etc. Currently, laser Doppler flowmetry is commonly used for blood flow measurement, however, relatively low resolution limits its application. Optical coherence tomography (OCT) is a powerful noninvasive 3D imaging modality with high temporal and spatial resolutions. Furthermore, OCT can provide flow distribution image by calculating Doppler frequency shift which makes it possible for blood flow rate measurement. In this paper, we applied OCT to measure the blood flow rate of the primary motor cortex in rats. The animal was immobilized and anesthetized with isoflurane, an incision was made along the sagittal suture, and bone was exposed. A skull window was opened on the primary motor cortex. Then, blood flow rate changes in the primary motor cortex were monitored by our homemade spectral domain OCT with a stimulation of the passive movement of the front legs. Finally, we established the relationship between blood flow rate and the test design. The aim is to demonstrate the potential of OCT in the evaluation of cerebral cortex function.

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Jian Liu, Yi Wang, Yuqian Zhao, Shidan Dou, Yushu Ma, and Zhenhe Ma "Measurement of cerebral blood flow rate and its relationship with brain function using optical coherence tomography", Proc. SPIE 9707, Dynamics and Fluctuations in Biomedical Photonics XIII, 97071D (17 March 2016); https://doi.org/10.1117/12.2214091

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KEYWORDS

Blood circulation

Optical coherence tomography

Velocity measurements

Doppler tomography

Blood vessels

Cerebral blood flow

Brain

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