Photoacoustic investigation of gold nanoshells for bioimaging applications

K. Sathiyamoorthy; Eric M. Strohm; Michael C. Kolios

doi:10.1117/12.2213766

22 April 2016 Photoacoustic investigation of gold nanoshells for bioimaging applications

K. Sathiyamoorthy, Eric M. Strohm, Michael C. Kolios

Proceedings Volume 9724, Plasmonics in Biology and Medicine XIII; 97240L (2016) https://doi.org/10.1117/12.2213766
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

In this study, we report photoacoustic (PA) measurements of gold-covered polystyrene nanoparticles (Au nanoshells). Two types of Au nanoshells were examined: 1) polystyrene core with sparsely covered Au nanoparticles, and 2) polystyrene core which were fully covered by Au nanoparticles. The fully covered Au nanoshell exhibited a broad extinction cross section (500 nm – 850 nm), which is in the first infrared optical window where light transmission is optimal for optical based studies in tissues. The optical properties were compared to numerical simulations using Mie scattering theory. Using a photoacoustic microscope, the PA signal measured from fully covered Au nanoshells was 1.27 ± 0.18 mV per fluence (mJ/cm2), which was 10x greater than the PA signal from sparsely covered Au nanoshells (0.12 ± 0.14 mV). These novel Au nanoshell nanoparticles can be used for multispectral optical and PA imaging.

Citation Download Citation

K. Sathiyamoorthy, Eric M. Strohm, and Michael C. Kolios "Photoacoustic investigation of gold nanoshells for bioimaging applications", Proc. SPIE 9724, Plasmonics in Biology and Medicine XIII, 97240L (22 April 2016); https://doi.org/10.1117/12.2213766

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