A 3D high resolution ex vivo white matter atlas of the common squirrel monkey (saimiri sciureus) based on diffusion tensor imaging

Yurui Gao; Prasanna Parvathaneni; Kurt G. Schilling; Feng Wang; Iwona Stepniewska; Zhoubing Xu; Ann S. Choe; Zhaohua Ding; John C. Gore; Li min Chen; Bennett A. Landman; Adam W. Anderson

doi:10.1117/12.2217325

21 March 2016 A 3D high resolution ex vivo white matter atlas of the common squirrel monkey (saimiri sciureus) based on diffusion tensor imaging

Yurui Gao, Prasanna Parvathaneni, Kurt G. Schilling, Feng Wang, Iwona Stepniewska, Zhoubing Xu, Ann S. Choe, Zhaohua Ding, John C. Gore, Li min Chen, Bennett A. Landman, Adam W. Anderson

Author Affiliations +

Proceedings Volume 9784, Medical Imaging 2016: Image Processing; 97843K (2016) https://doi.org/10.1117/12.2217325
Event: SPIE Medical Imaging, 2016, San Diego, California, United States

Abstract

Modern magnetic resonance imaging (MRI) brain atlases are high quality 3-D volumes with specific structures labeled in the volume. Atlases are essential in providing a common space for interpretation of results across studies, for anatomical education, and providing quantitative image-based navigation. Extensive work has been devoted to atlas construction for humans, macaque, and several non-primate species (e.g., rat). One notable gap in the literature is the common squirrel monkey – for which the primary published atlases date from the 1960’s. The common squirrel monkey has been used extensively as surrogate for humans in biomedical studies, given its anatomical neuro-system similarities and practical considerations. This work describes the continued development of a multi-modal MRI atlas for the common squirrel monkey, for which a structural imaging space and gray matter parcels have been previously constructed. This study adds white matter tracts to the atlas. The new atlas includes 49 white matter (WM) tracts, defined using diffusion tensor imaging (DTI) in three animals and combines these data to define the anatomical locations of these tracks in a standardized coordinate system compatible with previous development. An anatomist reviewed the resulting tracts and the inter-animal reproducibility (i.e., the Dice index of each WM parcel across animals in common space) was assessed. The Dice indices range from 0.05 to 0.80 due to differences of local registration quality and the variation of WM tract position across individuals. However, the combined WM labels from the 3 animals represent the general locations of WM parcels, adding basic connectivity information to the atlas.

Citation Download Citation

Yurui Gao, Prasanna Parvathaneni, Kurt G. Schilling, Feng Wang, Iwona Stepniewska, Zhoubing Xu, Ann S. Choe, Zhaohua Ding, John C. Gore, Li min Chen, Bennett A. Landman, and Adam W. Anderson "A 3D high resolution ex vivo white matter atlas of the common squirrel monkey (saimiri sciureus) based on diffusion tensor imaging", Proc. SPIE 9784, Medical Imaging 2016: Image Processing, 97843K (21 March 2016); https://doi.org/10.1117/12.2217325

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available