Seamless lesion insertion in digital mammography: methodology and reader study

Aria Pezeshk; Nicholas Petrick; Berkman Sahiner

doi:10.1117/12.2217056

24 March 2016 Seamless lesion insertion in digital mammography: methodology and reader study

Aria Pezeshk, Nicholas Petrick, Berkman Sahiner

Proceedings Volume 9785, Medical Imaging 2016: Computer-Aided Diagnosis; 97850J (2016) https://doi.org/10.1117/12.2217056
Event: SPIE Medical Imaging, 2016, San Diego, California, United States

Abstract

Collection of large repositories of clinical images containing verified cancer locations is costly and time consuming due to difficulties associated with both the accumulation of data and establishment of the ground truth. This problem poses a significant challenge to the development of machine learning algorithms that require large amounts of data to properly train and avoid overfitting. In this paper we expand the methods in our previous publications by making several modifications that significantly increase the speed of our insertion algorithms, thereby allowing them to be used for inserting lesions that are much larger in size. These algorithms have been incorporated into an image composition tool that we have made publicly available. This tool allows users to modify or supplement existing datasets by seamlessly inserting a real breast mass or micro-calcification cluster extracted from a source digital mammogram into a different location on another mammogram. We demonstrate examples of the performance of this tool on clinical cases taken from the University of South Florida Digital Database for Screening Mammography (DDSM). Finally, we report the results of a reader study evaluating the realism of inserted lesions compared to clinical lesions. Analysis of the radiologist scores in the study using receiver operating characteristic (ROC) methodology indicates that inserted lesions cannot be reliably distinguished from clinical lesions.

Citation Download Citation

Aria Pezeshk, Nicholas Petrick, and Berkman Sahiner "Seamless lesion insertion in digital mammography: methodology and reader study", Proc. SPIE 9785, Medical Imaging 2016: Computer-Aided Diagnosis, 97850J (24 March 2016); https://doi.org/10.1117/12.2217056

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