Translator Disclaimer
29 March 2016 Modeling the brain morphology distribution in the general aging population
Author Affiliations +
Both normal aging and neurodegenerative diseases such as Alzheimer’s disease cause morphological changes of the brain. To better distinguish between normal and abnormal cases, it is necessary to model changes in brain morphology owing to normal aging. To this end, we developed a method for analyzing and visualizing these changes for the entire brain morphology distribution in the general aging population. The method is applied to 1000 subjects from a large population imaging study in the elderly, from which 900 were used to train the model and 100 were used for testing. The results of the 100 test subjects show that the model generalizes to subjects outside the model population. Smooth percentile curves showing the brain morphology changes as a function of age and spatiotemporal atlases derived from the model population are publicly available via an interactive web application at
© (2016) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
W. Huizinga, D. H. J. Poot, G. Roshchupkin, E. E. Bron, M. A. Ikram, M. W. Vernooij, D. Rueckert, W. J. Niessen, and S. Klein "Modeling the brain morphology distribution in the general aging population", Proc. SPIE 9788, Medical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging, 97880I (29 March 2016);

Back to Top