Patient-specific simulation of tidal breathing

M. Walters; A. K. Wells; I. P. Jones; I. S. Hamill; B. Veeckmans; W. Vos; C. Lefevre; C. Fetitia

doi:10.1117/12.2216807

29 March 2016 Patient-specific simulation of tidal breathing

M. Walters, A. K. Wells, I. P. Jones, I. S. Hamill, B. Veeckmans, W. Vos, C. Lefevre, C. Fetitia

Author Affiliations +

Proceedings Volume 9788, Medical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging; 978818 (2016) https://doi.org/10.1117/12.2216807
Event: SPIE Medical Imaging, 2016, San Diego, California, United States

Abstract

Patient-specific simulation of air flows in lungs is now straightforward using segmented airways trees from CT scans as the basis for Computational Fluid Dynamics (CFD) simulations. These models generally use static geometries, which do not account for the motion of the lungs and its influence on important clinical indicators, such as airway resistance. This paper is concerned with the simulation of tidal breathing, including the dynamic motion of the lungs, and the required analysis workflow. Geometries are based on CT scans obtained at the extremes of the breathing cycle, Total Lung Capacity (TLC) and Functional Residual Capacity (FRC). It describes how topologically consistent geometries are obtained at TLC and FRC, using a ‘skeleton’ of the network of airway branches. From this a 3D computational mesh which morphs between TLC and FRC is generated. CFD results for a number of patient-specific cases, healthy and asthmatic, are presented. Finally their potential use in evaluation of the progress of the disease is discussed, focusing on an important clinical indicator, the airway resistance.

Citation Download Citation

M. Walters, A. K. Wells, I. P. Jones, I. S. Hamill, B. Veeckmans, W. Vos, C. Lefevre, and C. Fetitia "Patient-specific simulation of tidal breathing", Proc. SPIE 9788, Medical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging, 978818 (29 March 2016); https://doi.org/10.1117/12.2216807

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