Observations of liver cancer cells in scanning probe acoustic microscope: a preliminary study

Xiaohui Chen; Xiaoyue Fang; Qing Xi; Hua Guo; Ning Zhang; Mingyue Ding

doi:10.1117/12.2214333

1 April 2016 Observations of liver cancer cells in scanning probe acoustic microscope: a preliminary study

Xiaohui Chen, Xiaoyue Fang, Qing Xi, Hua Guo, Ning Zhang, Mingyue Ding

Proceedings Volume 9790, Medical Imaging 2016: Ultrasonic Imaging and Tomography; 97901T (2016) https://doi.org/10.1117/12.2214333
Event: SPIE Medical Imaging, 2016, San Diego, California, United States

Abstract

Scanning probe acoustic microscope (SPAM) can be used to acquire the morphology image as well as the non-destructive internal structures acoustic image. However, the observations of the morphology image as well as the internal structures acoustic image of liver cancer cells in SPAM are few. In this paper, we cultured 4 different types of liver cancer cells on the silicon wafer and coverslip to observe their morphology images as well as acoustic images in SPAM, and made a preliminary study of the 8 types of cells specimens (hereinafter referred to as the silicon specimens and coverslips specimens). The experimental measurement results showed that some cellular pseudopodium were observed in the morphology images of the coverslip specimens while no such cellular pseupodium were appeared in the morphology images of the silicon specimens, which concluded that the living liver cancer cells were less likely to grow on the silicon wafer. SPAM provides a rapid and sensitive visual method for studying the morphology and internal structures of the cancer cells. The proposed method can be also used to obtain the morphology and internal information in both solid and soft material wafers, such as silicon and cells, with the resolution of nanometer scale.

Citation Download Citation

Xiaohui Chen, Xiaoyue Fang, Qing Xi, Hua Guo, Ning Zhang, and Mingyue Ding "Observations of liver cancer cells in scanning probe acoustic microscope: a preliminary study", Proc. SPIE 9790, Medical Imaging 2016: Ultrasonic Imaging and Tomography, 97901T (1 April 2016); https://doi.org/10.1117/12.2214333

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available