Optical multi-frequency swept sensing for wide-field vibration measurement of interior surfaces in biological tissue

S. Choi; F. Nin; H. Hibino; T. Suzuki

doi:10.1117/12.2204984

9 December 2015 Optical multi-frequency swept sensing for wide-field vibration measurement of interior surfaces in biological tissue

S. Choi, F. Nin, H. Hibino, T. Suzuki

Author Affiliations +

Proceedings Volume 9792, Biophotonics Japan 2015; 97920Q (2015) https://doi.org/10.1117/12.2204984
Event: SPIE/OSJ Biophotonics Japan, 2015, Tokyo, Japan

Abstract

Multifrequency sensing technique adopting the wide field heterodyne detection technique is demonstrated for interior surface vibration measurements in thick biological tissue. These arrangements allow obtaining not only 3D tomographic images but also various vibration parameters such as spatial amplitude, phase, and frequency, with high temporal and transverse resolutions over a wide field. The axial resolution and the accuracy of vibration amplitude measurement were estimated to be 2.5 μm and 3 nm, respectively. This wide-field tomographic sensing method can be applied for measuring microdynamics of a variety of biological samples, thus contributing to the progress in life sciences research.

Citation Download Citation

S. Choi, F. Nin, H. Hibino, and T. Suzuki "Optical multi-frequency swept sensing for wide-field vibration measurement of interior surfaces in biological tissue", Proc. SPIE 9792, Biophotonics Japan 2015, 97920Q (9 December 2015); https://doi.org/10.1117/12.2204984

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