Photodynamic therapy with laser scanning mode of tumor irradiation

Oksana Chepurna; Irina Shton; Vladimir Kholin; Valerii Voytsehovich; Viacheslav Popov; Sergii Pavlov; Nikolai Gamaleia; Waldemar Wójcik; Maral Zhassandykyzy

doi:10.1117/12.2229030

17 December 2015 Photodynamic therapy with laser scanning mode of tumor irradiation

Oksana Chepurna, Irina Shton, Vladimir Kholin, Valerii Voytsehovich, Viacheslav Popov, Sergii Pavlov, Nikolai Gamaleia, Waldemar Wójcik, Maral Zhassandykyzy

Author Affiliations +

Proceedings Volume 9816, Optical Fibers and Their Applications 2015; 98161F (2015) https://doi.org/10.1117/12.2229030
Event: 16th Conference on Optical Fibers and Their Applications, 2015, Lublin and Naleczow, Poland

Abstract

In this study we propose a new version of photodynamic therapy performed by laser scanning. The method consists in tumor treatment by a light beam of a small cross section which incrementally moves through the chosen area with a defined delay at each point and repetitively re-scans a zone starting from the initial position. Experimental evaluation of the method in vitro on murine tumor model showed that despite the dose, applied by scanning irradiation mode, was 400 times lower, the tumor inhibition rate conceded to attained with continuous irradiation mode by only 20%.

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Oksana Chepurna, Irina Shton, Vladimir Kholin, Valerii Voytsehovich, Viacheslav Popov, Sergii Pavlov, Nikolai Gamaleia, Waldemar Wójcik, and Maral Zhassandykyzy "Photodynamic therapy with laser scanning mode of tumor irradiation", Proc. SPIE 9816, Optical Fibers and Their Applications 2015, 98161F (17 December 2015); https://doi.org/10.1117/12.2229030

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