Effect of pH on the morphology of kidney stones

Neelesh Agarwal; Stacey Sova; N. B. Singh; Brad Arnold; Fow-Sen Choa; Brian Cullum; Ching-Hua Su

doi:10.1117/12.2219939

13 May 2016 Effect of pH on the morphology of kidney stones

Neelesh Agarwal, Stacey Sova, N. B. Singh, Brad Arnold, Fow-Sen Choa, Brian Cullum, Ching-Hua Su

Proceedings Volume 9863, Smart Biomedical and Physiological Sensor Technology XIII; 986303 (2016) https://doi.org/10.1117/12.2219939
Event: SPIE Commercial + Scientific Sensing and Imaging, 2016, Baltimore, MD, United States

Abstract

The process for the formation of kidney stone is very complex phenomena and has some similarity to the crystal growth from a solution. It is very much dependent on the acidity pH of the fluids. This pH variation affects the content and amount of filtering residue and its morphology. In this study we have performed experiments using carbonate, oxides and urea to simulate and understand the morphologies of the residue filtered and coarsened in different conditions. We observed that different of morphologies of kidney stones can be explained on the basis of acidity and hydration conditions. At lower pH fat prism crystals are observed and as pH increases, long fat needle crystals with large aspect ratio are observed. The coarsening experiments showed further growth of crystals. The remelting experiments showed that during dissolution of kidney stones the joining material breaks first leaving the large faceted crystals undissolved when attempts are made to dissolve into small crystallites.

However, the morphology did not change. It was also observed that impurities such as magnesium oxide (MgO) affect the morphology significantly.

Citation Download Citation

Neelesh Agarwal, Stacey Sova, N. B. Singh, Brad Arnold, Fow-Sen Choa, Brian Cullum, and Ching-Hua Su "Effect of pH on the morphology of kidney stones", Proc. SPIE 9863, Smart Biomedical and Physiological Sensor Technology XIII, 986303 (13 May 2016); https://doi.org/10.1117/12.2219939

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