Bio-inspired patterned networks (BIPS) for development of wearable/disposable biosensors

E. S. McLamore; M. Convertino; John Hondred; Suprem Das; J. C. Claussen; D. C. Vanegas; C. Gomes

doi:10.1117/12.2223345

13 May 2016 Bio-inspired patterned networks (BIPS) for development of wearable/disposable biosensors

E. S. McLamore, M. Convertino, John Hondred, Suprem Das, J. C. Claussen, D. C. Vanegas, C. Gomes

Proceedings Volume 9863, Smart Biomedical and Physiological Sensor Technology XIII; 986309 (2016) https://doi.org/10.1117/12.2223345
Event: SPIE Commercial + Scientific Sensing and Imaging, 2016, Baltimore, MD, United States

Abstract

Here we demonstrate a novel approach for fabricating point of care (POC) wearable electrochemical biosensors based on 3D patterning of bionanocomposite networks. To create Bio-Inspired Patterned network (BIPS) electrodes, we first generate fractal network in silico models that optimize transport of network fluxes according to an energy function. Network patterns are then inkjet printed onto flexible substrate using conductive graphene ink. We then deposit fractal nanometal structures onto the graphene to create a 3D nanocomposite network. Finally, we biofunctionalize the surface with biorecognition agents using covalent bonding. In this paper, BIPS are used to develop high efficiency, low cost biosensors for measuring glucose as a proof of concept. Our results on the fundamental performance of BIPS sensors show that the biomimetic nanostructures significantly enhance biosensor sensitivity, accuracy, response time, limit of detection, and hysteresis compared to conventional POC non fractal electrodes (serpentine, interdigitated, and screen printed electrodes). BIPs, in particular Apollonian patterned BIPS, represent a new generation of POC biosensors based on nanoscale and microscale fractal networks that significantly improve electrical connectivity, leading to enhanced sensor performance.

Citation Download Citation

E. S. McLamore, M. Convertino, John Hondred, Suprem Das, J. C. Claussen, D. C. Vanegas, and C. Gomes "Bio-inspired patterned networks (BIPS) for development of wearable/disposable biosensors", Proc. SPIE 9863, Smart Biomedical and Physiological Sensor Technology XIII, 986309 (13 May 2016); https://doi.org/10.1117/12.2223345

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