Fast and accurate detection of cancer cell using a versatile three-channel plasmonic sensor

M. Hoseinian; A. R. Ahmadi; M. A. Bolorizadeh

doi:10.1117/12.2236357

17 September 2016 Fast and accurate detection of cancer cell using a versatile three-channel plasmonic sensor

M. Hoseinian, A. R. Ahmadi, M. A. Bolorizadeh

Proceedings Volume 9921, Plasmonics: Design, Materials, Fabrication, Characterization, and Applications XIV; 992127 (2016) https://doi.org/10.1117/12.2236357
Event: SPIE Nanoscience + Engineering, 2016, San Diego, California, United States

Abstract

Surface Plasmon Resonance (SPR) optical fiber sensors can be used as cost-effective small sized biosensors that are relatively simple to operate. Additionally, these instruments are label-free, hence rendering them highly sensitive to biological measurements. In this study, a three-channel microstructure optical fiber plasmonic-based portable biosensor is designed and analyzed using Finite Element Method. The proposed system is capable of determining changes in sample’s refractive index with precision of order one thousandth. The biosensor measures three absorption resonance wavelengths of the analytes simultaneously. This property is one of the main advantages of the proposed biosensor since it reduces the error in the measured wavelength and enhances the accuracy of the results up to 10^-5 m/RIU by reducing noise. In this paper, Jurkat cell, an indicator cell for leukemia cancer, is considered as the analyte; and its absorption resonance wavelengths as well as sensitivity in each channel are determined.

Citation Download Citation

M. Hoseinian, A. R. Ahmadi, and M. A. Bolorizadeh "Fast and accurate detection of cancer cell using a versatile three-channel plasmonic sensor", Proc. SPIE 9921, Plasmonics: Design, Materials, Fabrication, Characterization, and Applications XIV, 992127 (17 September 2016); https://doi.org/10.1117/12.2236357

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KEYWORDS

Sensors

Refractive index

Biosensors

Cancer

Surface plasmons

Dielectrics

Absorption

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