Numerical analysis for characterization of the gold nanorod mediated-plasmonic heating with temporary NIR laser radiation for superficial breast cancer therapy

Ji Yong Bae; Ki-Hwan Nam; Chan Bae Jeong; Geon-hee Kim; Ki Soo Chang

doi:10.1117/12.2236592

17 September 2016 Numerical analysis for characterization of the gold nanorod mediated-plasmonic heating with temporary NIR laser radiation for superficial breast cancer therapy

Ji Yong Bae, Ki-Hwan Nam, Chan Bae Jeong, Geon-hee Kim, Ki Soo Chang

Author Affiliations +

Proceedings Volume 9921, Plasmonics: Design, Materials, Fabrication, Characterization, and Applications XIV; 992129 (2016) https://doi.org/10.1117/12.2236592
Event: SPIE Nanoscience + Engineering, 2016, San Diego, California, United States

Abstract

Over the last decade, plasmonic photothermal therapy (PPTT) has received significant attention as the new therapeutic strategy for the cancer therapy due to unique characteristics of the gold-nanoparticles. The characterization of the spatiotemporal heating potential for the gold nanorods (GNR) through mimicking PPTT process on the various conditions can help more quantitative approaches to treatment planning. The purpose of this study was to clearly understand the optical-thermal interactions between the laser, GNRs, and bio-tissues, and provide the information in clinical applications to implement the concept of heterogeneity, which can enable the optimization of treatment parameters for superficial breast cancer treatment.

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Ji Yong Bae, Ki-Hwan Nam, Chan Bae Jeong, Geon-hee Kim, and Ki Soo Chang "Numerical analysis for characterization of the gold nanorod mediated-plasmonic heating with temporary NIR laser radiation for superficial breast cancer therapy", Proc. SPIE 9921, Plasmonics: Design, Materials, Fabrication, Characterization, and Applications XIV, 992129 (17 September 2016); https://doi.org/10.1117/12.2236592

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KEYWORDS

Laser therapeutics

Breast cancer

Tissues

Gold

Tissue optics

Nanorods

3D modeling

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