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A novel photoacoustic remote sensing (PARS) microscopy architecture is explored which replaces the traditional continuous-wave detection source with a pulse-sampling approach. This novel optical processing method is demonstrated on live vasculature networks with significant reductions in detection-source sample exposure by around two orders of magnitude. This architecture paves the way forward for more advanced proposed single-wavelength PARS architectures that may provide drastically improve performance in chromatic-sensitive scenarios such as posterior ophthalmic imaging and micro-endoscopy devices. Both the current pulsed-detection PARS and the proposed single-wavelength PARS are discussed and explored in detail.
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Kevan L. Bell, Benjamin Ecclestone, Parsin Haji Reza, "Towards single-wavelength photoacoustic remote sensing microscopy," Proc. SPIE PC11951, Design and Quality for Biomedical Technologies XV, PC119510H (7 March 2022); https://doi.org/10.1117/12.2607483