Discriminating turbid media by scatterer size and scattering coefficient using backscattered linearly and circularly polarized light

Michael Singh; Alex Vitkin

doi:10.1117/12.2608925

7 March 2022 Discriminating turbid media by scatterer size and scattering coefficient using backscattered linearly and circularly polarized light

Michael Singh, Alex Vitkin

Author Affiliations +

Proceedings Volume PC11963, Polarized Light and Optical Angular Momentum for Biomedical Diagnostics 2022; PC119630G (2022) https://doi.org/10.1117/12.2608925
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Precancer-to-cancer progression in epithelial tissues is marked by cellular proliferation and nuclear pleomorphism. These transformations have been shown to influence tissue optical properties: (1) tissue turbidity (quantified by the scattering coefficient) and (2) average scatterer size. It is found that backscattered polarized light can assess these properties. We use linear and circular depolarization to generate a predictive response surface where turbid media samples cluster by scatterer size and scattering coefficient. The novel polarimetric ability to noninvasively and simultaneously assess scatterer size and scattering coefficient of tissue-like turbid media may improve upon currently invasive skin cancer tests.

Conference Presentation

Citation Download Citation

Michael Singh and Alex Vitkin "Discriminating turbid media by scatterer size and scattering coefficient using backscattered linearly and circularly polarized light", Proc. SPIE PC11963, Polarized Light and Optical Angular Momentum for Biomedical Diagnostics 2022, PC119630G (7 March 2022); https://doi.org/10.1117/12.2608925

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available