Mapping the viscoelastic properties of breast carcinoma microenvironment by laser speckle rheological microscopy

Zeinab Hajjarian Kashany; Elena F. Brachtel; Diane Tshikudi; Seemantini Nadkarni

doi:10.1117/12.2610792

3 March 2022 Mapping the viscoelastic properties of breast carcinoma microenvironment by laser speckle rheological microscopy

Zeinab Hajjarian Kashany, Elena F. Brachtel, Diane Tshikudi, Seemantini Nadkarni

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Proceedings Volume PC11974, Biomedical Applications of Light Scattering XII; PC1197403 (2022) https://doi.org/10.1117/12.2610792
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Altered mechanical properties of tissue have emerged as both the cause and the consequence of tumorigenesis. Therefore, mapping the viscoelastic properties of tissue microenvironment provides crucial insights into micro-mechanical drivers of carcinogenesis. Here, we introduce laser Speckle rHEologicAl micRoscopy (SHEAR) that capture the time series of speckle patterns formed by multiple scattering of coherent light from tissue. We demonstrate that SHEAR rapidly maps the complex shear modulus, G*(x,y,ω), with 10’s µm resolution over multiple cm2, covering tumor epithelium, invasive front, and stroma. We further establish that G*(x,y,ω) maps yield micro-mechanical heterogeneity indices that closely correspond with tumor histopathology and prognosis.

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Zeinab Hajjarian Kashany, Elena F. Brachtel, Diane Tshikudi, and Seemantini Nadkarni "Mapping the viscoelastic properties of breast carcinoma microenvironment by laser speckle rheological microscopy", Proc. SPIE PC11974, Biomedical Applications of Light Scattering XII, PC1197403 (3 March 2022); https://doi.org/10.1117/12.2610792

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KEYWORDS

Breast

Speckle

Tumors

Microscopy

Light scattering

Tissues

Solids

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