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30 May 2022 Fast laser scanning imaging for single nanoparticle analysis
Lucas Oorlynck, Yera Y. Ussembayev, Juan C. Fraire, Charlotte Hinnekens, Kevin Braeckmans, Filip Strubbe
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Proceedings Volume PC12136, Unconventional Optical Imaging III; PC121360H (2022) https://doi.org/10.1117/12.2621702
Event: SPIE Photonics Europe, 2022, Strasbourg, France
Abstract
Nanoparticle-based applications require increasingly sensitive screening tools, necessitating single-particle, multi-parameter analysis techniques in the native liquid environment. In this work, we present a laser-scanning camera using acousto-optic deflectors and a single-photon counting module. By scanning a highly focused laser beam (532 nm) across a grid of pixels, and by detecting the associated emitted photons with high sensitivity, fluorescent nanoparticles of 100 nm and below can be imaged at frame rates up to 12 kHz.
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Lucas Oorlynck, Yera Y. Ussembayev, Juan C. Fraire, Charlotte Hinnekens, Kevin Braeckmans, and Filip Strubbe "Fast laser scanning imaging for single nanoparticle analysis", Proc. SPIE PC12136, Unconventional Optical Imaging III, PC121360H (30 May 2022); https://doi.org/10.1117/12.2621702
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KEYWORDS
Nanoparticles
Field programmable gate arrays
Photons
Single photon detectors
Particles
Motion analysis
Picosecond phenomena
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