Retinal characteristics of APPSL and 5xFAD mouse models of Alzheimer’s disease

Conrad W. Merkle; Antonia Lichtenegger; Jörg Neddens; Estibaliz Etxeberria; Stefanie Flunkert; Manuela Prokesch; Gerhard Garhöfer; Bernhard Baumann

doi:10.1117/12.2648864

17 March 2023 Retinal characteristics of APP_SL and ₅xFAD mouse models of Alzheimer’s disease

Conrad W. Merkle, Antonia Lichtenegger, Jörg Neddens, Estibaliz Etxeberria, Stefanie Flunkert, Manuela Prokesch, Gerhard Garhöfer, Bernhard Baumann

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Proceedings Volume PC12360, Ophthalmic Technologies XXXIII; PC1236012 (2023) https://doi.org/10.1117/12.2648864
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Alzheimer’s Disease (AD) is a degenerative neurological condition. Here, we use polarization-sensitive optical coherence tomography to characterize APPSL and 5xFAD mouse models for AD research. It was observed at approximately one year of age, both control and transgenic mice had developed similar retinal features, but AD models demonstrated significantly higher counts of hyperscattering foci compared to controls and some 5xFAD mice demonstrated a thickening of the photoreceptor layers. This study identifies potential AD biomarkers and reemphasizes the importance of using proper age-matched controls for animal studies, particularly when studying age-dependent diseases such as AD.

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Conrad W. Merkle, Antonia Lichtenegger, Jörg Neddens, Estibaliz Etxeberria, Stefanie Flunkert, Manuela Prokesch, Gerhard Garhöfer, and Bernhard Baumann "Retinal characteristics of APP_SL and ₅xFAD mouse models of Alzheimer’s disease", Proc. SPIE PC12360, Ophthalmic Technologies XXXIII, PC1236012 (17 March 2023); https://doi.org/10.1117/12.2648864

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