Elucidating photobiomodulation dosing via model-based estimates and direct light application at the nerve

Andrew Buzza; Kalista Tapas; Junqi Zhuo; Stephen Lewis; Juanita Anders; Michael Jenkins; Michael Moffitt

doi:10.1117/12.2648371

17 March 2023 Elucidating photobiomodulation dosing via model-based estimates and direct light application at the nerve

Andrew Buzza, Kalista Tapas, Junqi Zhuo, Stephen Lewis, Juanita Anders, Michael Jenkins, Michael Moffitt

Proceedings Volume PC12362, Mechanisms of Photobiomodulation Therapy XVII; PC123620A (2023) https://doi.org/10.1117/12.2648371
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Previous meta-analyses of photobiomodulation (PBM) parameters have reported correlations between effect size and emitter parameters, but the trends are not robust enough to prospectively predict doses that will yield a significant effect. A meta-analysis of PBM dosing protocols on peripheral nerves with 800 – 840 nm wavelength light was performed using Monte Carlo photon propagation models to elucidate clearer trends between dose and effect. We then tested various doses of PBM applied directly at exposed hindlimb nerve in a rodent pain model. A single application of PBM at the nerve reduced pain associated with heat-sensitive fibers for approximately 7 days.

Conference Presentation

Citation Download Citation

Andrew Buzza, Kalista Tapas, Junqi Zhuo, Stephen Lewis, Juanita Anders, Michael Jenkins, and Michael Moffitt "Elucidating photobiomodulation dosing via model-based estimates and direct light application at the nerve", Proc. SPIE PC12362, Mechanisms of Photobiomodulation Therapy XVII, PC123620A (17 March 2023); https://doi.org/10.1117/12.2648371

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