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9 March 2023 Influence of eye movements on functional signals in optoretinography
Clara Pfäffle, Svea Höhl, Hendrik Spahr, Léo Puyó, Jonas Franke, Gereon Hüttmann, Dierck Hillmann
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Proceedings Volume PC12367, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII; PC1236709 (2023) https://doi.org/10.1117/12.2652840
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
Phase-sensitive optoretiography is an emerging contrast method to assess the functional activity of retinal neurons in living humans. So far, functional signals were mostly observed in the photoreceptors. However, using full-field swept-source optical coherence tomography, additional signals were measured in the inner plexiform layer (IPL), which are linked to higher neuronal activity. Here, we investigated optoretinography signals for 6 different subjects and analyzed the influence of eye motionand the stability of two phase-evaluation algorithms. Thereby, photorceptor signals were observed in all and IPL signals in 85% of the measurements, with matching basic time courses and spatial signal-distribution for all subjects.
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Clara Pfäffle, Svea Höhl, Hendrik Spahr, Léo Puyó, Jonas Franke, Gereon Hüttmann, and Dierck Hillmann "Influence of eye movements on functional signals in optoretinography", Proc. SPIE PC12367, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII, PC1236709 (9 March 2023); https://doi.org/10.1117/12.2652840
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KEYWORDS
Eye
Optical coherence tomography
Neurons
Retina
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