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9 March 2023 Ionizing Radiation Acoustic Imaging (iRAI) for mapping the dose deep in the liver during radiation therapy
Wei Zhang, Ibrahim Oraiqat, Dale Litzenberg, Kai-Wei Chang, Scott Hadley, Noora Sunbul, Martha Matuszak, Christopher Tichacek, Eduardo Moros, Paul Carson, Kyle Cuneo, Xueding Wang, Issam El Naqa
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Proceedings Volume PC12379, Photons Plus Ultrasound: Imaging and Sensing 2023; PC1237907 (2023) https://doi.org/10.1117/12.2647771
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
Ionizing radiation acoustic imaging (iRAI) provides the potential to map the radiation dose during radiotherapy in real time. Described here is our recent development of an iRAI volumetric imaging system in mapping the three-dimensional (3D) radiation dose deposition of a complex clinical radiotherapy treatment plan. Temporal 3D dose accumulation of a treatment plan was first imaged in a phantom. Then, semi-quantitative iRAI measurements were verified with rabbit liver model in vivo. Finally, for the first time, real-time visualization of radiation dose delivered deep in a patient with liver metastases was successfully performed. These studies demonstrate the potential of iRAI to map the dose distribution in deep body during radiotherapy, potentially leading to personalized radiotherapy with optimal efficacy and safety.
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Wei Zhang, Ibrahim Oraiqat, Dale Litzenberg, Kai-Wei Chang, Scott Hadley, Noora Sunbul, Martha Matuszak, Christopher Tichacek, Eduardo Moros, Paul Carson, Kyle Cuneo, Xueding Wang, and Issam El Naqa "Ionizing Radiation Acoustic Imaging (iRAI) for mapping the dose deep in the liver during radiation therapy", Proc. SPIE PC12379, Photons Plus Ultrasound: Imaging and Sensing 2023, PC1237907 (9 March 2023); https://doi.org/10.1117/12.2647771
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KEYWORDS
Radiotherapy
Liver
Acoustics
Ionizing radiation
3D image processing
Imaging systems
Real time imaging
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