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9 March 2023 Photoacoustic and ultrasound image-guided cancer immunotherapy using nanoparticle-tagged T cells
Jinhwan Kim, Kelsey Kubelick, Myeongsoo Kim, Jeungyoon Lee, Anamik Jhunjhunwala, Anthony Yu, Stanislav Y. Emelianov
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Proceedings Volume PC12379, Photons Plus Ultrasound: Imaging and Sensing 2023; PC123790H (2023) https://doi.org/10.1117/12.2651460
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
In adoptive cell therapy (ACT) of solid tumors, only a small fraction of T cells typically accumulates at the target. Therefore, methods to noninvasively assess adoptive T cell infiltration are critical for ACT success. Here we present an approach based on photoacoustic (PA) and ultrasound (US) imaging to visualize nanoparticle (NP)-tagged adoptive T cells within tumor region. Our results indicate feasibility of the T cell tagging with NPs and US/PA imaging of adoptive T cells with clinically relevant spatial resolution and imaging depth thus providing critical imaging feedback to expedite development, translation, and expansion of ACT.
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Jinhwan Kim, Kelsey Kubelick, Myeongsoo Kim, Jeungyoon Lee, Anamik Jhunjhunwala, Anthony Yu, and Stanislav Y. Emelianov "Photoacoustic and ultrasound image-guided cancer immunotherapy using nanoparticle-tagged T cells", Proc. SPIE PC12379, Photons Plus Ultrasound: Imaging and Sensing 2023, PC123790H (9 March 2023); https://doi.org/10.1117/12.2651460
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KEYWORDS
Nanoparticles
Photoacoustic spectroscopy
Tumors
Ultrasonography
Cancer
Solids
Transmission electron microscopy
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