Nanoscale nuclear architecture mapping of early carcinogenesis (Conference Presentation)

Shikhar Uttam

doi:10.1117/12.2659388

16 March 2023 Nanoscale nuclear architecture mapping of early carcinogenesis (Conference Presentation)

Shikhar Uttam

Proceedings Volume PC12389, Quantitative Phase Imaging IX; PC123890O (2023) https://doi.org/10.1117/12.2659388
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Nanoscale nuclear architecture mapping (nanoNAM) is a label free imaging method based on the Fourier phase of Fourier-domain optical coherence tomography. It is capable of capturing, with nanoscale sensitivity, preneoplastic alterations in nuclear architecture of normal appearing cells undergoing malignant transformation both in animal models of carcinogenesis and human patients. In this talk I will present its theory and implementation from first principles and demonstrate its utility in a range of cancer settings. I will further present our recent results on testing the hypothesis that the ability of nanoNAM to capture early-stage malignant transformation is due to its sensitivity to the underlying aberrant structural alterations associated with chromatin remodeling during early stages of carcinogenesis. I will conclude by discussing its potential for use in the clinic.

Conference Presentation

Citation Download Citation

Shikhar Uttam "Nanoscale nuclear architecture mapping of early carcinogenesis (Conference Presentation)", Proc. SPIE PC12389, Quantitative Phase Imaging IX, PC123890O (16 March 2023); https://doi.org/10.1117/12.2659388

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KEYWORDS

Animal model studies

Cancer

Optical coherence tomography

Tumor growth modeling

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