1Computational Optics Group, Univ. of Tsukuba (Japan) 2Nikon Corp. (Japan) 3Damietta Univ. (Egypt) 4Center for Medical Physics and Biomedical Engineering, Medizinische Univ. Wien (Austria) 5Univ. of Tsukuba (Japan)
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We introduce volumetric differential contrast (VDC) imaging using optical coherence tomography (OCT). This method was designed based on a new theoretical model of OCT, the disperse scatterer model (DSM). VDC gives the differential image of “the product of the refractive index distribution and the scatterer density” through complex numerical processing of OCT signals.
The method was validated by in-vitro and in-vivo samples measured by spectral domain OCT. Differential contrast images with arbitrary shear amount and shear direction were obtained at arbitrary depth positions by a single measurement by numerically applying defocus by holographic signal processing after the signal acquisition.
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