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13 March 2024 Perspectives of usage of Fourier-transform infrared spectroscopy as fatality predictor for COVID-19 using serum samples
Herculano S. da Silva Martinho, Carla Carolina Silva Bandeira, Rodrigo Merlim Zerbinati, Paulo Henrique Braz-Silva, José Angelo Lauletta Lindoso
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Proceedings Volume PC12822, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2024; PC1282202 (2024) https://doi.org/10.1117/12.3005341
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
Role of antibodies in the worsening of COVID-19 disease is not obvious and its action in fatality cases is under debate. Our results using micro-Fourier-Transform Infrared reflectance spectroscopy (micro-FTIR) indicated that overall discrimination of healthy and COVID-19 individuals and severity prediction can be sucessfully implemented using for blood serum samples case (specificity =87.5 % ; sensisity = 100%.) Considering the minimal and reagent-free sample preparation procedures combined to fast (few minutes) outcome of FTIR we can state that this technology is very suitable for fast screening of immune response of individuals with COVID-19. It would be an important tool in prospective investigations, helping investigate the physiology of the asymptomatic, oligosymptomatic, or severe individuals and measure the extension of infection dissemination in patients.
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Herculano S. da Silva Martinho, Carla Carolina Silva Bandeira, Rodrigo Merlim Zerbinati, Paulo Henrique Braz-Silva, and José Angelo Lauletta Lindoso "Perspectives of usage of Fourier-transform infrared spectroscopy as fatality predictor for COVID-19 using serum samples", Proc. SPIE PC12822, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2024, PC1282202 (13 March 2024); https://doi.org/10.1117/12.3005341
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KEYWORDS
COVID 19
Infrared spectroscopy
Antibodies
Biological samples
Blood
Diseases and disorders
FT-IR spectroscopy
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