Real-time photodynamic therapy monitoring with ultrasound-guided photoacoustic imaging

Andrew Langley; Allison Sweeney; Brooke Bednarke; Faizah Wulandana; Srivalleesha Mallidi

doi:10.1117/12.3003211

19 March 2024 Real-time photodynamic therapy monitoring with ultrasound-guided photoacoustic imaging

Andrew Langley, Allison Sweeney, Brooke Bednarke, Faizah Wulandana, Srivalleesha Mallidi

Proceedings Volume PC12823, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXXII; PC128230E (2024) https://doi.org/10.1117/12.3003211
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

As photodynamic therapy is reliant on endogenous tumor oxygen to be successful, personalizing treatment to the patient is a necessary step to improving overall efficacy. We have demonstrated the feasibility of functionally imaging PDT in real-time, by mapping oxygen saturation as a surrogate marker for PDT progression with ultrasound-guided photoacoustic imaging in vivo. Particularly, we have deciphered the spatial map of the oxygen depletion rate during PDT as a function of fluence rate. Photoacoustic imaging importantly provides the temporal and spatial resolution, providing a novel platform for monitoring that can be used to inform personalized treatment in future work.

Conference Presentation

Citation Download Citation

Andrew Langley, Allison Sweeney, Brooke Bednarke, Faizah Wulandana, and Srivalleesha Mallidi "Real-time photodynamic therapy monitoring with ultrasound-guided photoacoustic imaging", Proc. SPIE PC12823, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXXII, PC128230E (19 March 2024); https://doi.org/10.1117/12.3003211

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