Photobiomodulation and the microbiome: clinical trial evidence for a mechanism for modulation of symptoms of Parkinson’s disease

Ann Liebert; Brian Bicknell; Sharon Tilley; John Mitrofanis; Hosen Kiat

doi:10.1117/12.3008806

13 March 2024 Photobiomodulation and the microbiome: clinical trial evidence for a mechanism for modulation of symptoms of Parkinson’s disease

Ann Liebert, Brian Bicknell, Sharon Tilley, John Mitrofanis, Hosen Kiat

Author Affiliations +

Proceedings Volume PC12826, Mechanisms of Photobiomodulation Therapy XVIII; PC1282601 (2024) https://doi.org/10.1117/12.3008806
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

There is a close association between the gut microbiome and metabolic and neurodegenerative diseases, especially in Parkinson’s disease. The potential of photobiomodulation to alleviate motor and non-motor symptoms of Parkinson’s disease has been demonstrated in animal experiments and proof-of-concept clinical trials. We have also previously shown that PBM can alter the gut microbiome in a mouse model, case studies and in a clinical trial of Parkinson’s disease. Here we present a clinical trial documenting changes in the microbiome of Parkinson’s participants with abdominal PBM that parallel changes in the symptoms of Parkinson’s disease and the disruption of the PBM effects by antibiotics.

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Citation Download Citation

Ann Liebert, Brian Bicknell, Sharon Tilley, John Mitrofanis, and Hosen Kiat "Photobiomodulation and the microbiome: clinical trial evidence for a mechanism for modulation of symptoms of Parkinson’s disease", Proc. SPIE PC12826, Mechanisms of Photobiomodulation Therapy XVIII, PC1282601 (13 March 2024); https://doi.org/10.1117/12.3008806

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