Human brain tissue identification using CARS and DRS for deep brain stimulation surgery

Mireille Quémener; Sébastien Jerczynski; Valérie Pineau Noël; Antoine Rousseau; Elahe Parham; Alexandre Bédard; Thomas Charland; Anthony Drouin; Jonathan Roussel; Valérie Dionne; Thomas Shooner; Anaïs Parrot; Shadi Masoumi; Damon DePaoli; Leo Cantin; Martin Parent; Daniel Côté

doi:10.1117/12.3000974

13 March 2024 Human brain tissue identification using CARS and DRS for deep brain stimulation surgery

Mireille Quémener, Sébastien Jerczynski, Valérie Pineau Noël, Antoine Rousseau, Elahe Parham, Alexandre Bédard, Thomas Charland, Anthony Drouin, Jonathan Roussel, Valérie Dionne, Thomas Shooner, Anaïs Parrot, Shadi Masoumi, Damon DePaoli, Leo Cantin, Martin Parent, Daniel Côté

Author Affiliations +

Proceedings Volume PC12831, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXII; PC1283103 (2024) https://doi.org/10.1117/12.3000974
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Deep brain stimulation (DBS) surgery is performed on patients suffering Parkinson’s disease for whom medication is no longer effective in relieving their motor symptoms. In this surgery, a stimulating electrode is implanted in a specific structure deep within the brain, delivering electrical impulses and thus reducing the motor symptoms. The success of the surgery is highly dependent on placing the electrode accurately in the targeted structure, typically the subthalamic nucleus (STN). We developed a DBS electrode that includes optical fibers to perform coherent anti-Stokes Raman scattering (CARS) spectroscopy and diffuse reflectance spectroscopy (DRS) during the electrode insertion in the brain. We were able to identify white and grey matter using principal component analysis (PCA), showing that spectroscopic measurements could be suitable for neuronavigation.

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Mireille Quémener, Sébastien Jerczynski, Valérie Pineau Noël, Antoine Rousseau, Elahe Parham, Alexandre Bédard, Thomas Charland, Anthony Drouin, Jonathan Roussel, Valérie Dionne, Thomas Shooner, Anaïs Parrot, Shadi Masoumi, Damon DePaoli, Leo Cantin, Martin Parent, and Daniel Côté "Human brain tissue identification using CARS and DRS for deep brain stimulation surgery", Proc. SPIE PC12831, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXII, PC1283103 (13 March 2024); https://doi.org/10.1117/12.3000974

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KEYWORDS

Brain tissue

Surgery

Brain stimulation

Lead

Tissue optics

Brain

Principal component analysis

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