Optical vortex tracking microrheology of turbid viscoelastic tissue

Qi Li; Jiaxing Gong; Jing Wang

doi:10.1117/12.3000752

13 March 2024 Optical vortex tracking microrheology of turbid viscoelastic tissue

Qi Li, Jiaxing Gong, Jing Wang

Proceedings Volume PC12844, Optical Elastography and Tissue Biomechanics XI; PC128440R (2024) https://doi.org/10.1117/12.3000752
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

We propose a novel optical microrheology technique that assesses tissue viscoelasticity by tracking the stochastic motion of optical vortices in speckles from turbid tissues. We validate the optical vortex tracking microrheology by illustrating the universal inverse relation between vortex displacements and the viscoelastic modulus. Moreover, we notice the phase angle of the viscoelastic sample is directly related to the vortices subdiffusion exponent. We also observe that the subdiffusion of optical vortices exhibits diverse characteristics for homogeneous and inhomogeneous samples. We believe the optical vortex tracking microrheology may find wide applications in different clinical scenarios like localizing tumors and fabricating biomaterials.

Conference Presentation

Citation Download Citation

Qi Li, Jiaxing Gong, and Jing Wang "Optical vortex tracking microrheology of turbid viscoelastic tissue", Proc. SPIE PC12844, Optical Elastography and Tissue Biomechanics XI, PC128440R (13 March 2024); https://doi.org/10.1117/12.3000752

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