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13 March 2024 Characterization and detection of colorectal cancer by multidimensional autofluorescence lifetime imaging: a preliminary study on surgical specimens
Alberto Ignacio Herrando M.D., Mireia Castillo Martin M.D., Antonio Galzerano M.D., Laura M. Fernández M.D., Pedro Vieira M.D., José Azevedo M.D., Amjad Parvaiz M.D., Vladislav Shcheslavskiy, Riccardo Cicchi, Pedro García Silva, João L. Lagarto
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Proceedings Volume PC12846, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XXII; PC128460G (2024) https://doi.org/10.1117/12.3001541
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
Autofluorescence lifetime measurements allow label-free differentiation of normal and diseased tissues. This study utilized mesoscopic autofluorescence imaging on colorectal cancer (CRC) surgical specimens from 73 patients, focusing on differentiating normal, adenomatous and cancerous tissues. Collagen and FAD achieved the highest discriminative power, while NADH revealed metabolic variability within tumors. Additionally, we studied the effect of radiation on rectal cancer autofluorescence signatures, aiming to develop a method for quantifying treatment response. Our findings demonstrate the sensitivity of autofluorescence lifetime measurements to radiation-induced changes, offering potential improvements in rectal cancer management. This research contributes to CRC assessment and advances personalized treatment approaches.
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Alberto Ignacio Herrando M.D., Mireia Castillo Martin M.D., Antonio Galzerano M.D., Laura M. Fernández M.D., Pedro Vieira M.D., José Azevedo M.D., Amjad Parvaiz M.D., Vladislav Shcheslavskiy, Riccardo Cicchi, Pedro García Silva, and João L. Lagarto "Characterization and detection of colorectal cancer by multidimensional autofluorescence lifetime imaging: a preliminary study on surgical specimens", Proc. SPIE PC12846, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XXII, PC128460G (13 March 2024); https://doi.org/10.1117/12.3001541
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KEYWORDS
Autofluorescence
Colorectal cancer
Cancer detection
Nicotinamide adenine dinucleotide
Tissues
Biomedical optics
Cancer
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