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4 January 2013 Light propagation in a turbid medium with insonified microbubbles
Terence S. Leung, Jack E. Honeysett, Eleanor Stride, Jing Deng
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Journal of Biomedical Optics, Vol. 18, Issue 1, 015002 (January 2013). https://doi.org/10.1117/1.JBO.18.1.015002
Abstract
Surfactant stabilized microbubbles are widely used clinical contrast agents for ultrasound imaging. In this work, the light propagation through a turbid medium in the presence of microbubbles has been investigated. Through a series of experiments, it has been found that the optical attenuation is increased when the microbubbles in a turbid medium are insonified by ultrasound. Such microbubble enhanced optical attenuation is a function of both applied ultrasound pressure and microbubble concentration. To understand the mechanisms involved, a Monte Carlo (MC) model has been developed. Under ultrasound exposure, the sizes of microbubbles vary in space and time, and their dynamics are modeled by the Rayleigh-Plesset equation. By using Mie theory, the spatially and temporally varying optical scattering and scattering efficiency of microbubbles are determined based on the bubble sizes and internal refractive indices. The MC model is shown to effectively describe a medium with rapidly changing optical scattering, and the results are validated against both computational results using an N-layered diffusion equation model and experimental results using a clinical microbubble contrast agent (SonoVue®).
CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
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Terence S. Leung, Jack E. Honeysett, Eleanor Stride, and Jing Deng "Light propagation in a turbid medium with insonified microbubbles," Journal of Biomedical Optics 18(1), 015002 (4 January 2013). https://doi.org/10.1117/1.JBO.18.1.015002
Published: 4 January 2013
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Cited by 6 scholarly publications.
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KEYWORDS
Ultrasonography
Scattering
Geometrical optics
Mie scattering
Acoustics
Reflectivity
Refractive index
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