CONFERENCE PROCEEDINGS
Advanced Search
Home > Journals > J. Biomed. Opt. > Volume 18 > Issue 12 > Article
Open Access
16 December 2013 Appearance of breast cysts in planar geometry photoacoustic mammography using 1064-nm excitation
Michelle Heijblom, Daniele Piras, Erik Maartens, Erik J. J. Huisman, Frank M. van den Engh, Joost M. Klaase, Wiendelt Steenbergen, Srirang Manohar
Author Affiliations +
Journal of Biomedical Optics, Vol. 18, Issue 12, 126009 (December 2013). https://doi.org/10.1117/1.JBO.18.12.126009
Abstract
In the search for improved imaging modalities for detection and diagnosis of breast cancer, a high negative prediction value is also important. Photoacoustic (optoacoustic) imaging is a relatively new technique that has high potential for visualizing breast malignancies, but little is known about the photoacoustic appearance of benign lesions. In this work, we investigate the visibility of benign breast cysts in forward-mode photoacoustic mammography using 1064-nm light, as currently applied in the Twente photoacoustic mammoscope. Results from (Monte Carlo and k-wave) simulations and phantom measurements were used to interpret results from patient measurements. There was a strong agreement among the results from simulations, phantom, and patient measurements. Depending on the absorption contrast between cyst and breast tissue, cysts were visible as either one or two confined high-contrast areas representing the front and the back of the cyst, respectively. This edge enhancement is most likely the consequence of the local sudden change in the absorbed energy density and Grüneisen coefficients. Although the current forward-mode single-wavelength photoacoustic mammoscope cannot always unambiguously discriminate cysts from malignancies, this study reveals specific features of cysts compared to malignancies, which can be exploited for discrimination of the two abnormalities in future modifications of the imager.
CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
Citation Download Citation
Michelle Heijblom, Daniele Piras, Erik Maartens, Erik J. J. Huisman, Frank M. van den Engh, Joost M. Klaase, Wiendelt Steenbergen, and Srirang Manohar "Appearance of breast cysts in planar geometry photoacoustic mammography using 1064-nm excitation," Journal of Biomedical Optics 18(12), 126009 (16 December 2013). https://doi.org/10.1117/1.JBO.18.12.126009
Published: 16 December 2013
JOURNAL ARTICLE
 12 PAGES
DOWNLOAD PAPER SAVE TO MY LIBRARY
GET CITATION
Lens.org Logo
CITATIONS
Cited by 23 scholarly publications.
Advertisement
Advertisement
KEYWORDS
Breast
Photoacoustic spectroscopy
Monte Carlo methods
Mammography
Absorption
Tissues
Acoustics
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top