CONFERENCE PROCEEDINGS
Advanced Search
Home > Journals > J. Biomed. Opt. > Volume 20 > Issue 11 > Article
Open Access
11 August 2015 Three-dimensional refractive index tomograms and deformability of individual human red blood cells from cord blood of newborn infants and maternal blood
HyunJoo Park, Taegyu Ahn, Kyoohyun Kim, Sangyun Lee, Song-yi Kook, Dongheon Lee, In Bum Suh, Sunghun Na, YongKeun Park
Author Affiliations +
Journal of Biomedical Optics, Vol. 20, Issue 11, 111208 (August 2015). https://doi.org/10.1117/1.JBO.20.11.111208
Abstract
Red blood cells (RBCs) from the cord blood of newborn infants have distinctive functions in fetal and infant development. To systematically investigate the biophysical characteristics of individual cord RBCs in newborn infants, a comparative study was performed on RBCs from the cord blood of newborn infants and from adult mothers or nonpregnant women using optical holographic microtomography. Optical measurements of the distributions of the three-dimensional refractive indices and the dynamic membrane fluctuations of individual RBCs were used to investigate the morphological, biochemical, and mechanical properties of cord, maternal, and adult RBCs at the individual cell level. The volume and surface area of the cord RBCs were significantly larger than those of the RBCs from nonpregnant women, and the cord RBCs had more flattened shapes than that of the RBCs in adults. In addition, the hemoglobin (Hb) content in the cord RBCs from newborns was significantly higher. The Hb concentration in the cord RBCs was higher than that in the nonpregnant women or maternal RBCs, but they were within the physiological range of adults. Interestingly, the amplitudes of the dynamic membrane fluctuations in cord RBCs were comparable to those in nonpregnant women and maternal RBCs, suggesting that the deformability of cord RBCs is similar to that of healthy RBCs in adults.
Park, Ahn, Kim, Lee, Kook, Lee, Suh, Na, and Park: Three-dimensional refractive index tomograms and deformability of individual human red blood cells from cord blood of newborn infants and maternal blood
© 2015 Society of Photo-Optical Instrumentation Engineers (SPIE) 1083-3668/2015/$25.00 © 2015 SPIE
Citation Download Citation
HyunJoo Park, Taegyu Ahn, Kyoohyun Kim, Sangyun Lee, Song-yi Kook, Dongheon Lee, In Bum Suh, Sunghun Na, and YongKeun Park "Three-dimensional refractive index tomograms and deformability of individual human red blood cells from cord blood of newborn infants and maternal blood," Journal of Biomedical Optics 20(11), 111208 (11 August 2015). https://doi.org/10.1117/1.JBO.20.11.111208
Published: 11 August 2015
JOURNAL ARTICLE
 8 PAGES
DOWNLOAD PAPER SAVE TO MY LIBRARY
GET CITATION
Lens.org Logo
CITATIONS
Cited by 43 scholarly publications.
Advertisement
Advertisement
RIGHTS & PERMISSIONS
Get copyright permission  Get copyright permission on Copyright Marketplace
KEYWORDS
Blood
Refractive index
Fetus
Optical testing
Oxygen
3D metrology
Diffraction
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top