Colposcopic imaging using visible-light optical coherence tomography

Lian Duan; Michael D. McRaven; Wenzhong Liu; Xiao Shu; Jianmin Hu; Cheng Sun; Ronald S. Veazey; Thomas J. Hope; Hao  F. Zhang

doi:10.1117/1.JBO.22.5.056003

8 May 2017 Colposcopic imaging using visible-light optical coherence tomography

Lian Duan, Michael D. McRaven, Wenzhong Liu, Xiao Shu, Jianmin Hu, Cheng Sun, Ronald S. Veazey, Thomas J. Hope, Hao F. Zhang

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Journal of Biomedical Optics, Vol. 22, Issue 5, 056003 (May 2017). https://doi.org/10.1117/1.JBO.22.5.056003

Abstract

High-resolution colposcopic optical coherence tomography (OCT) provides key anatomical measures, such as thickness and minor traumatic injury of vaginal epithelium, of the female reproductive tract noninvasively. This information can be helpful in both fundamental investigations in animal models and disease screenings in humans. We present a fiber-based visible-light OCT and two probe designs for colposcopic application. One probe conducts circular scanning using a DC motor, and the other probe is capable of three-dimensional imaging over a 4.6×4.6-mm2 area using a pair of galvo scanners. Using this colposcopic vis-OCT with both probes, we acquired high-resolution images from whole isolated macaque vaginal samples and identified biopsy lesions.

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Lian Duan, Michael D. McRaven, Wenzhong Liu, Xiao Shu, Jianmin Hu, Cheng Sun, Ronald S. Veazey, Thomas J. Hope, and Hao F. Zhang "Colposcopic imaging using visible-light optical coherence tomography," Journal of Biomedical Optics 22(5), 056003 (8 May 2017). https://doi.org/10.1117/1.JBO.22.5.056003

Received: 11 January 2017; Accepted: 17 April 2017; Published: 8 May 2017

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