Wide-field absolute transverse blood flow velocity mapping in vessel centerline

Nanshou Wu; Lei Wang; Bifeng Zhu; Caizhong Guan; Mingyi Wang; Dingan Han; Haishu Tan; Yaguang Zeng

doi:10.1117/1.JBO.23.2.026008

27 February 2018 Wide-field absolute transverse blood flow velocity mapping in vessel centerline

Nanshou Wu, Lei Wang, Bifeng Zhu, Caizhong Guan, Mingyi Wang, Dingan Han, Haishu Tan, Yaguang Zeng

Author Affiliations +

Journal of Biomedical Optics, Vol. 23, Issue 2, 026008 (February 2018). https://doi.org/10.1117/1.JBO.23.2.026008

Abstract

We propose a wide-field absolute transverse blood flow velocity measurement method in vessel centerline based on absorption intensity fluctuation modulation effect. The difference between the light absorption capacities of red blood cells and background tissue under low-coherence illumination is utilized to realize the instantaneous and average wide-field optical angiography images. The absolute fuzzy connection algorithm is used for vessel centerline extraction from the average wide-field optical angiography. The absolute transverse velocity in the vessel centerline is then measured by a cross-correlation analysis according to instantaneous modulation depth signal. The proposed method promises to contribute to the treatment of diseases, such as those related to anemia or thrombosis.

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Nanshou Wu, Lei Wang, Bifeng Zhu, Caizhong Guan, Mingyi Wang, Dingan Han, Haishu Tan, and Yaguang Zeng "Wide-field absolute transverse blood flow velocity mapping in vessel centerline," Journal of Biomedical Optics 23(2), 026008 (27 February 2018). https://doi.org/10.1117/1.JBO.23.2.026008

Received: 29 August 2017; Accepted: 5 February 2018; Published: 27 February 2018

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