Phase-contrast imaging with a compact x-ray light source: system design

Yongjin Sung; Rajiv Gupta; Brandon Nelson; Shuai Leng; Cynthia H. McCollough; William S. Graves

doi:10.1117/1.JMI.4.4.043503

23 November 2017 Phase-contrast imaging with a compact x-ray light source: system design

Yongjin Sung, Rajiv Gupta, Brandon Nelson, Shuai Leng, Cynthia H. McCollough, William S. Graves

Author Affiliations +

Funded by: Mayo Clinic, Arizona State University, US Army Medical Research and Materiel Command, U.S. Department of Defense (DOD), US Army Medical Research Materiel Command, Congressionally Directed Medical Research Programs (CDMRP), U.S. Army Medical Research Acquisition Activity (USAMRAA)

Journal of Medical Imaging, Vol. 4, Issue 4, 043503 (November 2017). https://doi.org/10.1117/1.JMI.4.4.043503

Abstract

X-ray phase-contrast imaging (XPCI) overcomes the problem of low contrast between different soft tissues achieved in conventional x-ray imaging by introducing x-ray phase as an additional contrast mechanism. This work describes a compact x-ray light source (CXLS) and compares, via simulations, the high quality XPCI results that can be produced from this source to those produced using a microfocus x-ray source. The simulation framework is first validated using an image acquired with a microfocus-source, propagation-based XPCI (PB-XPCI) system. The phase contrast for a water sphere simulating a simple cyst submersed in muscle is evaluated and the evolution of PB-XPCI signal as the object to detector distance is increased is demonstrated. The proposed design of a PB-XPCI system using the CXLS is described and simulated images of a coronary artery compared between CXLS and microfocus source PB-XPCI systems. To generate images with similar noise levels, a microfocus source would require a 3000 times longer exposure than would the CXLS. We conclude that CXLS technology has the potential to provide high-quality XPCI in a medical environment using extremely short exposure times relative to microfocus source approaches.

Citation Download Citation

Yongjin Sung, Rajiv Gupta, Brandon Nelson, Shuai Leng, Cynthia H. McCollough, and William S. Graves "Phase-contrast imaging with a compact x-ray light source: system design," Journal of Medical Imaging 4(4), 043503 (23 November 2017). https://doi.org/10.1117/1.JMI.4.4.043503

Received: 2 August 2017; Accepted: 6 November 2017; Published: 23 November 2017

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