Super-resolution imaging within reach

Stéphane Perrin; Paul Montgomery; Sylvain Lecler

doi:10.1117/1.OE.58.5.050501

13 May 2019 Super-resolution imaging within reach

Stéphane Perrin, Paul Montgomery, Sylvain Lecler

Author Affiliations +

Optical Engineering, Vol. 58, Issue 5, 050501 (May 2019). https://doi.org/10.1117/1.OE.58.5.050501

Abstract

Although several optical techniques have been developed to overcome the resolution limit in microscopy, the optical imaging of subwavelength features is still a real challenge (difficulty to build, or risks of phototoxicity). Microsphere-assisted microscopy has recently made super-resolution imaging accessible to scientists. An easy-to-implement optical setup to perform full-field and contactless super-resolution measurements using transparent microspheres is presented. We show that this rather simple imaging system (in comparison with the usual optical nanoscopes) makes it possible to achieve a lateral resolution of 200 nm in air and, thus, to visualize nanostructured media and biological elements.

Citation Download Citation

Stéphane Perrin, Paul Montgomery, and Sylvain Lecler "Super-resolution imaging within reach," Optical Engineering 58(5), 050501 (13 May 2019). https://doi.org/10.1117/1.OE.58.5.050501

Received: 12 February 2019; Accepted: 19 April 2019; Published: 13 May 2019

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