Dr. Adil Al-Mayah Profile

Dr. Adil Al-Mayah

Assistant Professor at Univ of Waterloo

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Proceedings Article | 24 February 2010 Paper

Biomechanical based image registration for head and neck radiation treatment

Adil Al-Mayah, Joanne Moseley, Shannon Hunter, Mike Velec, Lily Chau, Stephen Breen, Kristy Brock

Proceedings Volume 7625, 76250M (2010) https://doi.org/10.1117/12.845256

KEYWORDS: Image registration, Tumors, Head, Neck, Radiotherapy, Rigid registration, Computed tomography, 3D modeling, Finite element methods, Cancer

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Deformable image registration of four head and neck cancer patients was conducted using biomechanical based model. Patient specific 3D finite element models have been developed using CT and cone beam CT image data of the planning and a radiation treatment session. The model consists of seven vertebrae (C1 to C7), mandible, larynx, left and right parotid glands, tumor and body. Different combinations of boundary conditions are applied in the model in order to find the configuration with a minimum registration error. Each vertebra in the planning session is individually aligned with its correspondence in the treatment session. Rigid alignment is used for each individual vertebra and to the mandible since deformation is not expected in the bones. In addition, the effect of morphological differences in external body between the two image sessions is investigated. The accuracy of the registration is evaluated using the tumor, and left and right parotid glands by comparing the calculated Dice similarity index of these structures following deformation in relation to their true surface defined in the image of the second session. The registration improves when the vertebrae and mandible are aligned in the two sessions with the highest Dice index of 0.86±0.08, 0.84±0.11, and 0.89±0.04 for the tumor, left and right parotid glands, respectively. The accuracy of the center of mass location of tumor and parotid glands is also improved by deformable image registration where the error in the tumor and parotid glands decreases from 4.0±1.1, 3.4±1.5, and 3.8±0.9 mm using rigid registration to 2.3±1.0, 2.5±0.8 and 2.0±0.9 mm in the deformable image registration when alignment of vertebrae and mandible is conducted in addition to the surface projection of the body.

Proceedings Article | 13 March 2009 Paper

Effect of heterogeneous material of the lung on deformable image registration

Adil Al-Mayah, Joanne Moseley, Mike Velec, Kristy Brock

Proceedings Volume 7261, 72610V (2009) https://doi.org/10.1117/12.813828

KEYWORDS: Lung, Motion models, Image registration, Finite element methods, 3D modeling, Tumors, Tissues, Lawrencium, Chest, Mechanics

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Patient specific 3D finite element models have been developed to investigate the effect of heterogeneous material properties on modeling of the deformation of the lungs by including the bronchial trees of each lung. Each model consists of both lungs, body, tumor, and bronchial trees. Triangular shell elements with 0.1 cm wall thickness are used to model the bronchial trees. Body, lungs and tumor are modeled using 4-node tetrahedral elements. Experimental test data are used for the nonlinear material properties of the lungs. Three elastic modulii of 0.5, 10 and 18 MPa are used for the bronchial tree. Frictionless contact surfaces are applied to lung surfaces and cavities. The accuracy of the results is examined using an average of 40 bifurcation points. Preliminary results have shown an insignificant effect of modeling the bronchial trees explicitly on the overall accuracy of the model. However, local changes in the predicted motion of the bronchial tree of up to 5.2 mm were observed, indicating that modeling the bronchial tree explicitly, with unique material properties, may ensure a more accurately detailed model of the lung as well as reduced maximum residual errors.

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