Prof. Alex Hartov Profile

Prof. Alex Hartov

Associate Professor/Engineering at Thayer School of Engineering at Dartmouth

SPIE Involvement:

Author

Publications (33)

Proceedings Article | 4 April 2022 Presentation + Paper

Patient registration using intraoperative stereovision for open cranial surgery

Xiaoyao Fan, Alex Hartov, David Roberts, Keith Paulsen

Proceedings Volume 12034, 1203406 (2022) https://doi.org/10.1117/12.2611488

KEYWORDS: Image registration, Surgery, Head, Brain, Skin, Microscopes, Image segmentation, Neuroimaging

Read Abstract +

Proceedings Article | 18 March 2016 Paper

Image updating for brain deformation compensation in tumor resection

Xiaoyao Fan, Songbai Ji, Jonathan Olson, David Roberts, Alex Hartov, Keith Paulsen

Proceedings Volume 9786, 97862A (2016) https://doi.org/10.1117/12.2217223

KEYWORDS: Brain, Finite element methods, Neuroimaging, Optical flow, Magnetic resonance imaging, Image registration, Surgery, Tissues, Tumors, Motion models, Image segmentation, Volume rendering, Data modeling

Read Abstract +

Proceedings Article | 18 March 2015 Paper

A multimodal imaging framework for enhanced robot-assisted partial nephrectomy guidance

Ryan Halter, Xiaotian Wu, Alex Hartov, John Seigne, Shadab Khan

Proceedings Volume 9415, 94151E (2015) https://doi.org/10.1117/12.2082775

KEYWORDS: Kidney, Magnetic resonance imaging, Tumors, Surgery, Computed tomography, Image registration, 3D image processing, Cameras, Laparoscopy, Calibration

Read Abstract +

Proceedings Article | 12 March 2013 Paper

Measuring soft tissue material properties using stereovision and indentation: a proof-of-concept study

Songbai Ji, Xiaoyao Fan, Alex Hartov, David Roberts, Keith Paulsen

Proceedings Volume 8671, 86710V (2013) https://doi.org/10.1117/12.2008041

KEYWORDS: Tissues, Natural surfaces, Brain, In vivo imaging, Optical tracking, Cameras, Optical flow, Motion models, Microscopes, 3D modeling

Read Abstract +

Proceedings Article | 12 March 2013 Paper

Integration of intraoperative and model-updated images into an industry-standard neuronavigation system: initial results

Timothy Schaewe, Xiaoyao Fan, Songbai Ji, Alex Hartov, Leslie Hiemenz Holton, David Roberts, Keith Paulsen, David Simon

Proceedings Volume 8671, 867119 (2013) https://doi.org/10.1117/12.2007987

KEYWORDS: 3D modeling, Data modeling, Brain, Magnetic resonance imaging, Image processing, Process modeling, Neuroimaging, Surgery, Ultrasonography, Tumors

Read Abstract +

Proceedings Article | 8 March 2013 Paper

Retractor-induced brain shift compensation in image-guided neurosurgery

Xiaoyao Fan, Songbai Ji, Alex Hartov, David Roberts, Keith Paulsen

Proceedings Volume 8671, 86710K (2013) https://doi.org/10.1117/12.2007685

KEYWORDS: Brain, Data modeling, Neuroimaging, Tissues, Natural surfaces, Surgery, 3D modeling, Magnetic resonance imaging, Clouds, Neodymium

Read Abstract +

Proceedings Article | 25 February 2012 Open Access

Integration of 3D intraoperative ultrasound for enhanced neuronavigation

Keith Paulsen, Songbai Ji, Alex Hartov, Xiaoyao Fan, David Roberts

Proceedings Volume 8320, 83200S (2012) https://doi.org/10.1117/12.915588

KEYWORDS: 3D image processing, 3D acquisition, Image registration, 3D modeling, Ultrasonography, Transducers, Data modeling, Brain, Model-based design, Calibration

Read Abstract +

DOWNLOAD PAPER

Proceedings Article | 17 February 2012 Paper

Registering stereovision surface with preoperative magnetic resonance images for brain shift compensation

Xiaoyao Fan, Songbai Ji, Alex Hartov, David Roberts, Keith Paulsen

Proceedings Volume 8316, 83161C (2012) https://doi.org/10.1117/12.911081

KEYWORDS: Brain, Neuroimaging, Magnetic resonance imaging, Data modeling, Volume rendering, Image registration, 3D image processing, Neodymium, Photography, 3D modeling

Read Abstract +

Proceedings Article | 2 March 2011 Paper

Optimizing nonrigid registration performance between volumetric true 3D ultrasound images in image-guided neurosurgery

Songbai Ji, Xiaoyao Fan, David Roberts, Alex Hartov, Keith Paulsen

Proceedings Volume 7964, 79640V (2011) https://doi.org/10.1117/12.878353

KEYWORDS: Image registration, Data modeling, Brain, Ultrasonography, Magnetic resonance imaging, Tissues, Neuroimaging, Surgery, 3D image processing, 3D modeling

Read Abstract +

Proceedings Article | 2 March 2011 Paper

Simulation of brain tumor resection in image-guided neurosurgery

Xiaoyao Fan, Songbai Ji, Kathryn Fontaine, Alex Hartov, David Roberts, Keith Paulsen

Proceedings Volume 7964, 79640U (2011) https://doi.org/10.1117/12.878104

KEYWORDS: Brain, Data modeling, Tissues, Natural surfaces, Neuroimaging, Tumors, Ultrasonography, 3D modeling, Surgery, Magnetic resonance imaging

Read Abstract +

Preoperative magnetic resonance images are typically used for neuronavigation in image-guided neurosurgery. However, intraoperative brain deformation (e.g., as a result of gravitation, loss of cerebrospinal fluid, retraction, resection, etc.) significantly degrades the accuracy in image guidance, and must be compensated for in order to maintain sufficient accuracy for navigation. Biomechanical finite element models are effective techniques that assimilate intraoperative data and compute whole-brain deformation from which to generate model-updated MR images (uMR) to improve accuracy in intraoperative guidance. To date, most studies have focused on early surgical stages (i.e., after craniotomy and durotomy), whereas simulation of more complex events at later surgical stages has remained to be a challenge using biomechanical models. We have developed a method to simulate partial or complete tumor resection that incorporates intraoperative volumetric ultrasound (US) and stereovision (SV), and the resulting whole-brain deformation was used to generate uMR. The 3D ultrasound and stereovision systems are complimentary to each other because they capture features deeper in the brain beneath the craniotomy and at the exposed cortical surface, respectively. In this paper, we illustrate the application of the proposed method to simulate brain tumor resection at three temporally distinct surgical stages throughout a clinical surgery case using sparse displacement data obtained from both the US and SV systems. We demonstrate that our technique is feasible to produce uMR that agrees well with intraoperative US and SV images after dural opening, after partial tumor resection, and after complete tumor resection. Currently, the computational cost to simulate tumor resection can be up to 30 min because of the need for re-meshing and the trial-and-error approach to refine the amount of tissue resection. However, this approach introduces minimal interruption to the surgical workflow, which suggests the potential for its clinical application with further improvement in computational efficiency.

Proceedings Article | 3 March 2010 Paper

An integrated model-based neurosurgical guidance system

Songbai Ji, Xiaoyao Fan, Kathryn Fontaine, Alex Hartov, David Roberts, Keith Paulsen

Proceedings Volume 7625, 762536 (2010) https://doi.org/10.1117/12.843499

KEYWORDS: Brain, Image registration, Data modeling, Surgery, Computational modeling, Calibration, Imaging systems, Model-based design, Systems modeling, Neuroimaging

Read Abstract +

Proceedings Article | 24 February 2010 Paper

Graphical user interfaces for simulation of brain deformation in image-guided neurosurgery

Xiaoyao Fan, Songbai Ji, Pablo Valdes, David Roberts, Alex Hartov, Keith Paulsen

Proceedings Volume 7625, 762535 (2010) https://doi.org/10.1117/12.844036

KEYWORDS: Brain, Neuroimaging, Data modeling, Image segmentation, Image registration, Ultrasonography, Magnetic resonance imaging, Human-machine interfaces, Visualization, 3D image processing

Read Abstract +

Proceedings Article | 13 March 2009 Paper

Brain tumor resection guided by fluorescence imaging and MRI image guidance

Pablo Valdes, Brent Harris, Frederic Leblond, Kathryn Fontaine, Songbai Ji, Brian Pogue, Alex Hartov, David Roberts, Keith Paulsen

Proceedings Volume 7261, 726103 (2009) https://doi.org/10.1117/12.813868

KEYWORDS: Magnetic resonance imaging, Luminescence, Tissues, Tumors, Microscopes, Brain, Gadolinium, Surgery, Image analysis, Image enhancement

Read Abstract +

Proceedings Article | 13 March 2009 Paper

Model-based brain shift compensation in image-guided neurosurgery

Songbai Ji, Fenghong Liu, Xiaoyao Fan, Alex Hartov, David Roberts, Keith Paulsen

Proceedings Volume 7261, 72612E (2009) https://doi.org/10.1117/12.813704

KEYWORDS: Tumors, Brain, Image registration, Data modeling, Neuroimaging, Model-based design, 3D image processing, 3D modeling, Image segmentation, Visualization

Read Abstract +

Proceedings Article | 24 February 2009 Paper

Brain tumor resection guided by fluorescence imaging

Frederic Leblond, Kathryn Fontaine, Pablo Valdes, Songbai Ji, Brian Pogue, Alex Hartov, David Roberts, Keith Paulsen

Proceedings Volume 7164, 71640M (2009) https://doi.org/10.1117/12.808928

KEYWORDS: Tumors, Luminescence, Surgery, Microscopes, Tissues, Brain, Magnetic resonance imaging, Navigation systems, Neuroimaging, Clinical trials

Read Abstract +

Proceedings Article | 17 March 2008 Paper

Mutual-information-corrected tumor displacement using intraoperative ultrasound for brain shift compensation in image-guided neurosurgery

Songbai Ji, Alex Hartov, David Roberts, Keith Paulsen

Proceedings Volume 6918, 69182H (2008) https://doi.org/10.1117/12.770363

KEYWORDS: Tumors, Image registration, Data modeling, Brain, Image segmentation, Neuroimaging, Surgery, Ultrasonography, Head, Magnetic resonance imaging

Read Abstract +

Proceedings Article | 17 March 2008 Paper

Coregistered volumetric true 3D ultrasonography in image-guided neurosurgery

Songbai Ji, Alex Hartov, Kathryn Fontaine, Andrea Borsic, David Roberts, Keith Paulsen

Proceedings Volume 6918, 69180F (2008) https://doi.org/10.1117/12.770382

KEYWORDS: 3D image processing, Image registration, 3D acquisition, Visualization, Ultrasonography, Transducers, Image visualization, Image acquisition, Tumors, Composites

Read Abstract +

Proceedings Article | 22 March 2007 Paper

A surface misfit inversion method for brain deformation modeling

Fenghong Liu, Keith Paulsen, Alexander Hartov, David Roberts

Proceedings Volume 6509, 65092L (2007) https://doi.org/10.1117/12.710234

KEYWORDS: Data modeling, Brain, Image registration, Iterative methods, Protactinium, Data processing, Neuroimaging, Motion models, Data acquisition, Tumor growth modeling

Read Abstract +

Proceedings Article | 22 March 2007 Paper

Brain-skull boundary conditions in a neurosurgery deformation model

Songbai Ji, Fenghong Liu, David Roberts, Alex Hartov, Keith Paulsen

Proceedings Volume 6509, 65092J (2007) https://doi.org/10.1117/12.709641

KEYWORDS: Brain, Skull, Chemical elements, Motion models, Tumors, Neuroimaging, Interfaces, Mathematical modeling, Computer simulations, Injuries

Read Abstract +

Proceedings Article | 10 March 2006 Paper

Comparative study of brain deformation estimation methods

Fenghong Liu, Keith Paulsen, Karen Lunn, Hai Sun, Alexander Hartov, Ziji Wu, David Roberts

Proceedings Volume 6141, 61411D (2006) https://doi.org/10.1117/12.654821

KEYWORDS: Fused deposition modeling, Brain, Tumors, Data modeling, Overlay metrology, Finite element methods, Motion models, Mathematical modeling, Tissues, Protactinium

Read Abstract +

Proceedings Article | 12 April 2005 Paper

Quantifying brain shift during neurosurgery using spatially tracked ultrasound

Tico Blumenthal, Alex Hartov, Karen Lunn, Francis Kennedy, David Roberts, Keith Paulsen

Proceedings Volume 5744, (2005) https://doi.org/10.1117/12.594515

KEYWORDS: Brain, Ultrasonography, Data modeling, Image segmentation, Magnetic resonance imaging, Tissues, Tumors, Natural surfaces, Computed tomography, Neuroimaging

Read Abstract +

Proceedings Article | 30 May 2003 Paper

Inverse technique for combined model and sparse data estimates of brain motion

Karen Lunn, Keith Paulsen, David Roberts, Francis Kennedy, Alex Hartov

Proceedings Volume 5029, (2003) https://doi.org/10.1117/12.479720

KEYWORDS: Data modeling, Brain, Magnetic resonance imaging, Motion models, Ultrasonography, Tissues, Tumors, Error analysis, 3D modeling, Systems modeling

Read Abstract +

Proceedings Article | 30 May 2003 Paper

Graphical user interface for intraoperative neuroimage updating

Kyle Rick, Alex Hartov, David Roberts, Karen Lunn, Hai Sun, Keith Paulsen

Proceedings Volume 5029, (2003) https://doi.org/10.1117/12.479761

KEYWORDS: Brain, Surgery, Ultrasonography, Neuroimaging, Magnetic resonance imaging, Data modeling, Tissues, Human-machine interfaces, Finite element methods, Head

Read Abstract +

Proceedings Article | 30 May 2003 Paper

Using cortical vessels for patient registration during image-guided neurosurgery: a phantom study

Hai Sun, David Roberts, Alex Hartov, Kyle Rick, Keith Paulsen

Proceedings Volume 5029, (2003) https://doi.org/10.1117/12.479723

KEYWORDS: Image registration, Microscopes, Cameras, Image segmentation, Error analysis, Calibration, Brain, 3D image processing, Space operations, Imaging systems

Read Abstract +

Proceedings Article | 17 May 2002 Paper

Extracting displacement data from coregistered ultrasound for brain modeling

Karen Lunn, Alex Hartov, David Roberts, Hai Sun, Keith Paulsen

Proceedings Volume 4681, (2002) https://doi.org/10.1117/12.466945

KEYWORDS: Ultrasonography, Computed tomography, Tissues, Brain, Image registration, Data modeling, Neuroimaging, Magnetic resonance imaging, Rigid registration, Systems modeling

Read Abstract +

Proceedings Article | 17 May 2002 Paper

Real-time correction scheme for calibration and implementation of microscope-based image-guided neurosurgery

Hai Sun, Hany Farid, Alex Hartov, Karen Lunn, David Roberts, Keith Paulsen

Proceedings Volume 4681, (2002) https://doi.org/10.1117/12.466967

KEYWORDS: Calibration, Microscopes, Cameras, 3D image processing, Surgery, Image registration, Brain, 3D acquisition, Imaging systems, Tissues

Read Abstract +

Proceedings Article | 1 June 2001 Paper

Is penile electrocautery safe?: I. Histological and computational temperature assessment in an animal model

P. Jack Hoopes, David Cozzolino, Marc Cendron, Keith Paulsen, B. Stuart Trembly, Alex Hartov, Thomas Ryan, Luanna Bartholomew

Proceedings Volume 4247, (2001) https://doi.org/10.1117/12.427846

KEYWORDS: Tissues, Penis, Temperature metrology, Skin, Surgery, Injuries, Animal model studies, Fiber optics, Inflammation, Tissue optics

Read Abstract +

Proceedings Article | 30 May 2001 Paper

3D ultrasound as sparse data for intraoperative brain deformation model

Karen Lunn, Alex Hartov, Francis Kennedy, Michael Miga, David Roberts, Leah Platenik, Keith Paulsen

Proceedings Volume 4325, (2001) https://doi.org/10.1117/12.428208

KEYWORDS: Ultrasonography, Calibration, Magnetic resonance imaging, 3D modeling, Brain, Data modeling, Neuroimaging, Optical tracking, Reticles, Image segmentation

Read Abstract +

Proceedings Article | 28 May 2001 Paper

Comparison of an incremental versus single-step retraction model for intraoperative compensation

Leah Platenik, Michael Miga, David Roberts, Francis Kennedy, Alex Hartov, Karen Lunn, Keith Paulsen

Proceedings Volume 4319, (2001) https://doi.org/10.1117/12.428075

KEYWORDS: Brain, Tissues, 3D modeling, Computed tomography, Neuroimaging, Image registration, In vivo imaging, Distortion, Surgery, Natural surfaces

Read Abstract +

Proceedings Article | 28 May 2001 Paper

Finite element modeling of tissue retraction and resection for preoperative neuroimage compensation concurrent with surgery

Keith Paulsen, Michael Miga, David Roberts, Francis Kennedy, Leah Platenik, Karen Lunn, Alex Hartov

Proceedings Volume 4319, (2001) https://doi.org/10.1117/12.428039

KEYWORDS: Tissues, Motion models, Surgery, Brain, Natural surfaces, Mathematical modeling, Finite element methods, Electrodes, Chemical elements, Data modeling

Read Abstract +

Proceedings Article | 24 January 2000 Open Access

Electromagnetic methods for thermal therapy monitoring and assessment

Keith Paulsen, Alex Hartov, Paul Meaney

Proceedings Volume 10297, 102970J (2000) https://doi.org/10.1117/12.375220

KEYWORDS: Electromagnetism, Tissues, Tomography, Microwave imaging

Read Abstract +

DOWNLOAD PAPER

Proceedings Article | 13 May 1998 Paper

Modeling surgical loads to account for subsurface tissue deformation during stereotactic neurosurgery

Michael Miga, Keith Paulsen, Francis Kennedy, P. Jack Hoopes, Alex Hartov, David Roberts

Proceedings Volume 3254, (1998) https://doi.org/10.1117/12.308202

KEYWORDS: Tissues, Brain, Motion models, Protactinium, Magnetic resonance imaging, In vivo imaging, Data modeling, Computed tomography, Ultrasonography, 3D modeling

Read Abstract +

Proceedings Article | 2 April 1998 Paper

Electrical impedance imaging for tissue monitoring and assessment during thermal therapy

Keith Paulsen, Alex Hartov, Kendra Osterman, Rob Mazzarese, Todd Kerner

Proceedings Volume 3249, (1998) https://doi.org/10.1117/12.304343

KEYWORDS: Tissues, Analog electronics, Electrodes, Data acquisition, Image restoration, Injuries, Digital electronics, In vivo imaging, Tumors, Radiotherapy

Read Abstract +

Showing 5 of 33 publications

Conference Committee Involvement (2)

Physiology, Function, and Structure from Medical Images

18 February 2007 | San Diego, CA, United States

Physiology, Function, and Structure from Medical Images

12 February 2006 | San Diego, California, United States

View contact details

UPDATE YOUR PROFILE

Is this your profile? Update it now.

Sign into your SPIE.org account

Don’t have a profile and want one?

Create an account on SPIE.org

Keywords/Phrases

Search In:

Publication Years